{"id":"W2079623756","doi":"10.1038/mt.2010.124","title":"Recognition of Virus Infection and Innate Host Responses to Viral Gene Therapy Vectors","year":2010,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Virology; Innate immune system; Host (biology); Biology; Genetic enhancement; Virus; Gene; Vector (molecular biology); Vectors in gene therapy; Viral vector; Immunology; Genetics; Immune system; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003871635,0.0004641046,0.001090467,0.000553167,0.0001062653,0.00002818533,0.0002059718,0.0008058465,0.0002721871],"category_scores_gemma":[0.000100159,0.0003691416,0.0003803407,0.0002316499,0.0001811459,0.00005163238,0.00006201889,0.0006209649,0.0002762986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003616893,"about_ca_system_score_gemma":0.0001322323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001904881,"about_ca_topic_score_gemma":0.000009281628,"domain_scores_codex":[0.9975086,0.001170253,0.0005398049,0.0004238184,0.00005103361,0.0003064619],"domain_scores_gemma":[0.9989522,0.0001598197,0.0003029085,0.0004404029,0.0001140203,0.00003072695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008102016,0.0000698903,0.000002836517,0.00009371871,0.0002702207,0.000004604638,0.00008011387,1.195674e-8,0.4425657,0.000007680662,0.00003289169,0.5560621],"study_design_scores_gemma":[0.0005397047,0.0008648573,0.00007658408,0.000508115,0.00005242191,0.00009385058,0.000002182602,1.50589e-8,0.3733247,0.00001417029,0.6242672,0.0002561338],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2762264,0.7221999,0.00005795191,0.00001638797,0.0006078376,0.0007024695,0.00009563536,0.00004237769,0.00005099001],"genre_scores_gemma":[0.002733439,0.9960229,0.00004589557,0.0002321945,0.00003014709,0.0001389269,0.0002285175,0.00007946331,0.000488447],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6242344,"threshold_uncertainty_score":0.9998761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03614803860165269,"score_gpt":0.313376192816046,"score_spread":0.2772281542143933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}