{"id":"W2079623756","doi":"10.1038/mt.2010.124","title":"Recognition of Virus Infection and Innate Host Responses to Viral Gene Therapy Vectors","year":2010,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Virology; Innate immune system; Host (biology); Biology; Genetic enhancement; Virus; Gene; Vector (molecular biology); Vectors in gene therapy; Viral vector; Immunology; Genetics; Immune system; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006420332,0.001137296,0.00138866,0.001402085,0.0002402247,0.0009260252,0.000872402,0.001593827,0.00205533],"category_scores_gemma":[0.0005335723,0.0002946786,0.0002842173,0.001114972,0.0008610861,0.001377533,0.0004513731,0.002426059,0.001792744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007879779,"about_ca_system_score_gemma":0.0007120703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000655507,"about_ca_topic_score_gemma":0.001601558,"domain_scores_codex":[0.9998422,0.00002581606,0.00001934559,0.00002793997,0.0000695265,0.00001526802],"domain_scores_gemma":[0.9997455,0.0001294239,0.00003215327,0.00000961128,0.0000594166,0.00002376708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001025477,0.00008986836,0.0001283588,0.005852812,0.00003747836,0.000271635,0.00004471742,0.0003502663,0.008804019,0.007036286,0.04029449,0.9369873],"study_design_scores_gemma":[0.00002483953,0.00007327613,0.0004267615,0.001079926,0.00004958849,0.001957514,0.00003806602,0.0001496432,0.002432929,0.002917049,0.9908345,0.00001586356],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001551701,0.9961841,0.0006959736,0.0003945531,0.0007309105,0.000006512993,0.000009421355,0.000009589781,0.001813834],"genre_scores_gemma":[0.001156654,0.9941806,0.0007096775,0.000452899,0.0007650232,0.0000175005,0.00003153886,0.000003278408,0.002682772],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00205533,"threshold_uncertainty_score":0.006875694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03614803860165269,"score_gpt":0.313376192816046,"score_spread":0.2772281542143933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}