{"id":"W2079660989","doi":"10.1021/op100113j","title":"Development of a Pilot-Plant-Scale Synthesis of an Alkylated Dihydrobenzothiadiazole <i>S</i>,<i>S</i>-Dioxide: Incorporation of a Late-Stage Mitsunobu Reaction","year":2010,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Chemical Synthesis and Reactions","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Mitsunobu reaction; Chemistry; Oxidizing agent; Alkylation; Organic chemistry; Extraction (chemistry); Combinatorial chemistry; Bleach; Active ingredient; Aqueous solution; Aniline; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001363378,0.0002840475,0.0005457544,0.0003115915,0.000254208,0.0000235185,0.0006079921,0.000306316,0.0009726527],"category_scores_gemma":[0.0006908649,0.0002588127,0.0000654956,0.0008489808,0.0002489445,0.0002982502,0.0001803235,0.0007081598,0.00001907173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002305206,"about_ca_system_score_gemma":0.001676144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001093447,"about_ca_topic_score_gemma":0.001353249,"domain_scores_codex":[0.9963191,0.0000567281,0.001233921,0.000545261,0.001321328,0.0005236611],"domain_scores_gemma":[0.9974406,0.0002931588,0.000621016,0.0005393736,0.0008274367,0.0002783583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001885782,0.001221627,0.000699496,0.0009499455,0.0001175271,0.000002666862,0.001386253,0.000006734458,0.9837454,0.00001635635,0.00002545805,0.01163997],"study_design_scores_gemma":[0.0002786559,0.00002950577,0.00149441,0.0003942204,0.00002304754,0.000006302437,0.0006465371,0.0000749281,0.9943079,0.00007633532,0.002392569,0.000275574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966455,0.00003334026,0.00003276342,0.00005404568,0.00005716596,0.0002346187,0.00006093051,0.00006861072,0.002813017],"genre_scores_gemma":[0.9924898,0.00006875997,0.006616447,0.000004141059,0.00004036313,0.0001378774,0.0001458447,0.00005921049,0.0004376241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0113644,"threshold_uncertainty_score":0.9999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866656966589338,"score_gpt":0.2947374213394158,"score_spread":0.2660708516735225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}