{"id":"W2079660989","doi":"10.1021/op100113j","title":"Development of a Pilot-Plant-Scale Synthesis of an Alkylated Dihydrobenzothiadiazole <i>S</i>,<i>S</i>-Dioxide: Incorporation of a Late-Stage Mitsunobu Reaction","year":2010,"lang":"en","type":"article","venue":"Organic Process Research & Development","topic":"Chemical Synthesis and Reactions","field":"Chemistry","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Mitsunobu reaction; Chemistry; Oxidizing agent; Alkylation; Organic chemistry; Extraction (chemistry); Combinatorial chemistry; Bleach; Active ingredient; Aqueous solution; Aniline; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000285516,0.0005837393,0.0004901577,0.0002432407,0.0002670652,0.0003292591,0.0005076755,0.0004052155,0.002261721],"category_scores_gemma":[0.0002364361,0.0002786854,0.0004054688,0.0002101933,0.0001945349,0.0002685146,0.000272007,0.0006841489,0.001627988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000375083,"about_ca_system_score_gemma":0.0007651274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001577624,"about_ca_topic_score_gemma":0.002834919,"domain_scores_codex":[0.9998179,0.00001928147,0.00001256472,0.00004092044,0.00008209927,0.00002729559],"domain_scores_gemma":[0.9998633,0.00002102196,0.00002287643,0.00002510877,0.00003266878,0.00003498981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002598115,0.00003731686,0.00005452366,0.00004304916,0.000003944268,0.0000506996,0.00001125643,0.0001397716,0.9975756,0.00004821558,0.0000452861,0.001964456],"study_design_scores_gemma":[0.00002450918,0.0004717337,0.0005825244,0.000002224132,0.00001526175,0.0001283049,0.00001387136,0.0007176029,0.9951195,0.00002142529,0.002896028,0.000007048035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8670918,0.0006387417,0.1177714,0.000284698,0.0001668485,0.00198486,0.002194246,0.002001351,0.007866077],"genre_scores_gemma":[0.8478703,0.001065244,0.1384861,0.0001072838,0.00004548561,0.0005949051,0.002664986,0.0002560835,0.008909527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002261721,"threshold_uncertainty_score":0.007566214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866656966589338,"score_gpt":0.2947374213394158,"score_spread":0.2660708516735225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}