{"id":"W2079677576","doi":"10.1016/j.stemcr.2014.08.005","title":"Human Bone Marrow Stromal Cells Lose Immunosuppressive and Anti-inflammatory Properties upon Oncogenic Transformation","year":2014,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Instituto de Salud Carlos III; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Proinflammatory cytokine; Stromal cell; Biology; Transcriptome; Immune system; Cancer research; Cell biology; Bone marrow; Immunology; Inflammation; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001121631,0.0003153349,0.0005760916,0.0002037347,0.0002551331,0.00008595415,0.00009296212,0.0002103002,0.0001857137],"category_scores_gemma":[0.00002386753,0.0002556806,0.0001513368,0.0001309155,0.0001425082,0.000264741,0.0000871371,0.0003862315,0.0000590182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168708,"about_ca_system_score_gemma":0.0001688958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006680305,"about_ca_topic_score_gemma":0.00001074138,"domain_scores_codex":[0.9968558,0.0001945448,0.00094301,0.0005419276,0.0008933644,0.0005713784],"domain_scores_gemma":[0.9983122,0.00004207485,0.0003731177,0.0007100055,0.0002144757,0.0003481282],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009480195,0.0001118794,0.003155631,0.001316046,0.00004416823,0.0009935824,0.0009398725,0.00001361691,0.9887536,0.00002718399,0.000341012,0.004208564],"study_design_scores_gemma":[0.00132824,0.0005806888,0.007867033,0.0003917743,0.0001242963,0.001286432,0.0005602355,0.0004314768,0.9783738,0.00002670133,0.008673013,0.0003562595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720171,0.00135973,0.0000368727,0.0001084195,0.000229663,0.001289007,0.000002659897,0.0001073959,0.02484915],"genre_scores_gemma":[0.9912357,0.0000850123,0.00005929375,0.00003081317,0.0001533891,0.00005489862,0.00002607559,0.00005898539,0.008295815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01921861,"threshold_uncertainty_score":0.9999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01673067914698236,"score_gpt":0.2473458785173797,"score_spread":0.2306151993703973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}