{"id":"W2079688281","doi":"10.1074/jbc.m203313200","title":"Ligand-independent Activation of the Androgen Receptor by Interleukin-6 and the Role of Steroid Receptor Coactivator-1 in Prostate Cancer Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Medical Research and Materiel Command; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; U.S. Department of Defense","keywords":"Coactivator; Proto-oncogene tyrosine-protein kinase Src; LNCaP; Androgen receptor; Transactivation; Phosphorylation; Cell biology; Cancer research; Chemistry; Receptor; Biology; Ligand (biochemistry); Prostate cancer; Cancer; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001741743,0.0003169523,0.0002194473,0.0003554774,0.0002038287,0.0004213107,0.0002735837,0.0003095941,0.001080129],"category_scores_gemma":[0.0001048008,0.0001668444,0.0003658616,0.0003244331,0.000232939,0.0002066487,0.0002319214,0.0009009385,0.0007795863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003272472,"about_ca_system_score_gemma":0.0002544471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008972787,"about_ca_topic_score_gemma":0.0009505099,"domain_scores_codex":[0.9998112,0.00003170659,0.00001179166,0.00002272482,0.00007920758,0.000043284],"domain_scores_gemma":[0.9999077,0.00001225964,0.0000180807,0.0000131752,0.00001977804,0.00002891148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004698122,0.0002064972,0.001057848,0.0004137455,0.00002161911,0.0004908399,0.00009134603,0.0002330664,0.9793348,0.00126636,0.0008591331,0.01555491],"study_design_scores_gemma":[0.0002302659,0.001790764,0.1324707,0.0001054207,0.0000920431,0.004674297,0.0002738828,0.003479893,0.7852845,0.0011841,0.07034926,0.00006488015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.766354,0.2038753,0.008683823,0.002424558,0.00066286,0.0001338819,0.001582936,0.0003535255,0.0159291],"genre_scores_gemma":[0.9459883,0.04205039,0.001781535,0.0003610934,0.000191176,0.00007794186,0.002123205,0.00001737076,0.007408895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080129,"threshold_uncertainty_score":0.003613353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005420071295010404,"score_gpt":0.2057613349746984,"score_spread":0.200341263679688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}