{"id":"W2079709085","doi":"10.1152/ajpheart.00636.2012","title":"ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4","year":2013,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"PDK4; Internal medicine; Endocrinology; Insulin resistance; Pyruvate dehydrogenase complex; Angiotensin II; Pyruvate dehydrogenase kinase; Insulin; Heart failure; Pyruvate decarboxylation; Chemistry; Biology; Metabolism; Medicine; Citric acid cycle; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009118114,0.0002989646,0.0002639551,0.0001969342,0.0001087175,0.0002350805,0.0001444007,0.0001689061,0.001220832],"category_scores_gemma":[0.00006657474,0.0001333696,0.0003252454,0.0001276999,0.0001676424,0.0001404539,0.0001641783,0.0006842715,0.000135399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001810683,"about_ca_system_score_gemma":0.0001015281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001851724,"about_ca_topic_score_gemma":0.0002217164,"domain_scores_codex":[0.999923,0.00001159227,0.000008855644,0.00001904462,0.00001911574,0.00001849696],"domain_scores_gemma":[0.9999427,0.0000048805,0.00002069252,0.000005818099,0.000004515869,0.00002140487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005556372,0.00007444994,0.001030489,0.00004813795,0.00002123343,0.0001457776,0.000007785447,0.0000485062,0.9959436,0.00007671864,0.00006396446,0.001983624],"study_design_scores_gemma":[0.0001757495,0.002169748,0.08573596,0.00001871951,0.0001440684,0.002095965,0.00007775384,0.002920133,0.9023381,0.0003237026,0.003981659,0.00001846796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995288,0.001780981,0.001774905,0.000148416,0.00004929889,0.00001482456,0.0001630232,0.00006851527,0.0007119493],"genre_scores_gemma":[0.9971268,0.0008381099,0.0007271303,0.00008965674,0.0000129396,0.00001716477,0.0001906536,0.00001096272,0.0009865869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001220832,"threshold_uncertainty_score":0.004084051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008158975082412727,"score_gpt":0.242666189578931,"score_spread":0.2345072144965183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}