{"id":"W2079709085","doi":"10.1152/ajpheart.00636.2012","title":"ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4","year":2013,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"PDK4; Internal medicine; Endocrinology; Insulin resistance; Pyruvate dehydrogenase complex; Angiotensin II; Pyruvate dehydrogenase kinase; Insulin; Heart failure; Pyruvate decarboxylation; Chemistry; Biology; Metabolism; Medicine; Citric acid cycle; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002256381,0.0002003565,0.001196445,0.0001804353,0.000136172,0.000007606778,0.00005770743,0.0001040802,0.00003720771],"category_scores_gemma":[0.0001133882,0.0001492112,0.0002285919,0.0002117254,0.001535315,0.0001310822,0.00007270349,0.0003445839,0.000002176663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001208985,"about_ca_system_score_gemma":0.0001045097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001324318,"about_ca_topic_score_gemma":0.000002613766,"domain_scores_codex":[0.9985992,0.0002322619,0.000420416,0.0003185231,0.0001642787,0.0002653175],"domain_scores_gemma":[0.9988586,0.0001653634,0.0002310073,0.0002285485,0.0002743727,0.0002421601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001424569,0.00008885842,0.01172626,0.00004410725,0.0003254829,2.580198e-7,0.0006576541,0.000002535195,0.9853621,0.0001287493,0.0001151009,0.001406507],"study_design_scores_gemma":[0.0005826029,0.0008031811,0.9879847,0.00004484657,0.0002711763,0.0001275905,0.002135386,0.00001267943,0.005011833,0.000569348,0.002314098,0.0001425132],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860164,0.01333926,7.709625e-7,0.0002978028,0.0001690573,0.0001300453,0.00000686999,0.00001124457,0.00002853889],"genre_scores_gemma":[0.9974205,0.001772811,0.0001621207,0.0003652779,0.0002436167,0.000008424343,0.000002410787,0.00001655388,0.000008274757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9803502,"threshold_uncertainty_score":0.6084656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008158975082412727,"score_gpt":0.242666189578931,"score_spread":0.2345072144965183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}