{"id":"W2079724400","doi":"10.1111/j.1471-4159.2006.03837.x","title":"Molecular morphology and toxicity of cytoplasmic prion protein aggregates in neuronal and non‐neuronal cells","year":2006,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Medical Research Council; Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Cytoplasm; Aggresome; Cell biology; Cytoplasmic inclusion; Biology; Biochemistry; Autophagy; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257776,0.0001510312,0.0002169248,0.00005459837,0.00002419456,0.00001589757,0.0001416146,0.000118441,0.000006149038],"category_scores_gemma":[0.00007465728,0.000149129,0.00007924187,0.0000608646,0.0001112627,0.000008293075,0.0001134811,0.0001891024,1.580546e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007264742,"about_ca_system_score_gemma":0.00006812517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005539789,"about_ca_topic_score_gemma":8.768902e-7,"domain_scores_codex":[0.9990084,0.00005057385,0.0003939751,0.0002264347,0.0001479856,0.0001726853],"domain_scores_gemma":[0.9993607,0.00001729259,0.0003303278,0.0001303276,0.00007297694,0.00008831869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000196403,0.00008603986,0.003066232,0.00009492257,0.00001006076,0.00009273532,0.000004284142,0.0001669184,0.9953014,0.000003440637,0.00003861649,0.0009389099],"study_design_scores_gemma":[0.0008008998,0.0002903297,0.01953297,0.00006097654,0.00001529548,0.0002759485,0.000006962068,0.00005451151,0.9784086,0.0001318302,0.0003041629,0.0001174847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953557,0.004239107,0.0000865189,0.0001303812,0.00003353732,0.0000994747,0.00001111199,0.000001833693,0.00004239252],"genre_scores_gemma":[0.998617,0.0007417967,0.000416819,0.00009515245,0.00008618499,0.000002717402,0.000005607849,0.00001520133,0.00001954534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01689281,"threshold_uncertainty_score":0.6081305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00345589236843269,"score_gpt":0.2053785780784636,"score_spread":0.2019226857100309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}