{"id":"W2079739732","doi":"10.1016/j.healun.2003.11.294","title":"Optimal time point to predict cyclosporine, tacrolimus and mycophenoic acid area-under-the-curve (AUC)0-12 hr in long-term heart/heart-lung transplant patients","year":2004,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Transplantation: Methods and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; McGill University Health Centre","funders":"","keywords":"Tacrolimus; Mycophenolic acid; Therapeutic drug monitoring; Mycophenolate; Medicine; Trough level; Heart transplantation; Area under the curve; Urology; Therapeutic effect; Immunosuppressive drug; Lung transplantation; Drug; Cardiology; Lung; Internal medicine; Pharmacology; Heart failure; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001570005,0.0005025544,0.0012722,0.0005019356,0.0002416485,0.001134597,0.0002228828,0.0009420732,0.0007132174],"category_scores_gemma":[0.004891506,0.0001610501,0.0007494136,0.000406358,0.0002710567,0.0006444719,0.0002847774,0.00112228,0.0002484041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004049711,"about_ca_system_score_gemma":0.000586889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001353427,"about_ca_topic_score_gemma":0.001104179,"domain_scores_codex":[0.9994116,0.000257536,0.00006278999,0.00009026311,0.00007829388,0.00009956384],"domain_scores_gemma":[0.9963629,0.002018766,0.0004228498,0.00009524093,0.0003338736,0.0007664383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01190729,0.0004111017,0.9607769,0.00004767843,0.0002828688,0.0002245839,0.0001121695,0.003947484,0.002962945,0.0001327141,0.0007642959,0.01843005],"study_design_scores_gemma":[0.0003891788,0.006249608,0.9471614,0.00005238059,0.0005694632,0.001142745,0.0003520113,0.03864305,0.003995383,0.0005502907,0.0008263623,0.00006796638],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971302,0.0008689193,0.00102273,0.0001578234,0.00004508971,0.00001337112,0.0001547214,0.00003562131,0.0005715503],"genre_scores_gemma":[0.9987844,0.0001216824,0.0006224611,0.00005420635,0.00002529357,0.000009464991,0.0002309341,0.000007433182,0.0001441798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001570005,"threshold_uncertainty_score":0.008303046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01064635728847066,"score_gpt":0.2779469786230004,"score_spread":0.2673006213345298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}