{"id":"W2079740756","doi":"10.1074/jbc.m112.436352","title":"Mechanism of Action of Neisseria gonorrhoeae O-Acetylpeptidoglycan Esterase, an SGNH Serine Esterase","year":2012,"lang":"es","type":"article","venue":"Journal of Biological Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Esterase; Neisseria gonorrhoeae; Catalytic triad; Serine; Oxyanion hole; Active site; Hydrolase; Peptidoglycan; Biochemistry; Stereochemistry; Chemistry; Structural similarity; Enzyme; Binding site; Protein superfamily; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660706,0.0005559392,0.0003202537,0.0001282812,0.0002222372,0.0004843119,0.0004470571,0.0005444994,0.0008245886],"category_scores_gemma":[0.0001459938,0.0001600423,0.0003934122,0.00005000691,0.0003088276,0.0003759557,0.0002128705,0.0003920083,0.0003150666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003950002,"about_ca_system_score_gemma":0.0003141395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001241308,"about_ca_topic_score_gemma":0.0004499455,"domain_scores_codex":[0.9999268,0.00001202231,0.00000389595,0.00001735962,0.00002328579,0.00001665605],"domain_scores_gemma":[0.9999571,0.000009251481,0.000008582921,0.000004058339,0.000009670102,0.00001140504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003799422,0.0001200113,0.002043815,0.0004202233,0.00004695118,0.001060337,0.00009413578,0.00464229,0.9731035,0.0045839,0.0003420905,0.01316281],"study_design_scores_gemma":[0.0001222041,0.00105686,0.00744967,0.0000445365,0.0000524052,0.001954488,0.0002263465,0.04769326,0.9309244,0.001710174,0.008719253,0.00004646325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9497547,0.01268744,0.02496856,0.0007341448,0.0001747541,0.0002868524,0.0003864755,0.0002454464,0.01076168],"genre_scores_gemma":[0.9911093,0.002883039,0.004013008,0.00004912263,0.00001090849,0.00004604832,0.0001063926,0.000005303484,0.001777023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241308,"threshold_uncertainty_score":0.002865911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04496304377853347,"score_gpt":0.2867488525650513,"score_spread":0.2417858087865179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}