{"id":"W2079740756","doi":"10.1074/jbc.m112.436352","title":"Mechanism of Action of Neisseria gonorrhoeae O-Acetylpeptidoglycan Esterase, an SGNH Serine Esterase","year":2012,"lang":"es","type":"article","venue":"Journal of Biological Chemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Canadian Institutes of Health Research","keywords":"Esterase; Neisseria gonorrhoeae; Catalytic triad; Serine; Oxyanion hole; Active site; Hydrolase; Peptidoglycan; Biochemistry; Stereochemistry; Chemistry; Structural similarity; Enzyme; Binding site; Protein superfamily; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007530415,0.0006102461,0.001391273,0.00005681654,0.00007704848,0.00005435529,0.0007392714,0.001056207,0.003254242],"category_scores_gemma":[0.0005025418,0.0005040557,0.0007521883,0.0002648804,0.0003191485,0.000446249,0.0001872137,0.0008658654,0.000005485941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000186767,"about_ca_system_score_gemma":0.0001706779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001617416,"about_ca_topic_score_gemma":4.91144e-7,"domain_scores_codex":[0.9966387,0.0001128523,0.001936532,0.0003873427,0.0002743139,0.0006502801],"domain_scores_gemma":[0.9951164,0.0002999455,0.00272269,0.0007012823,0.0004428107,0.0007169358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001101369,0.001465386,0.007847315,0.001752515,0.0003142614,0.00001630759,0.0001720968,0.00001581661,0.9849544,0.00003513066,0.00004397614,0.002281425],"study_design_scores_gemma":[0.0009625461,0.0002820063,0.0009349577,0.0005782195,0.0002810559,0.0005579386,0.001255428,0.00004146835,0.9929023,0.00009886058,0.001622558,0.0004826029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955744,0.001000256,0.00004126612,0.00008823211,0.0002893574,0.00007083973,0.00021541,0.00002432859,0.002695982],"genre_scores_gemma":[0.9964705,0.0008581488,0.0004825652,0.00002742858,0.001730254,0.000005069032,0.00007269212,0.00004427417,0.0003090828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007947958,"threshold_uncertainty_score":0.9997411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04496304377853347,"score_gpt":0.2867488525650513,"score_spread":0.2417858087865179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}