{"id":"W2079744596","doi":"10.1016/j.jmb.2010.07.059","title":"Measuring “Unmeasurable” Folding Kinetics of Proteins by Single-Molecule Force Spectroscopy","year":2010,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Folding (DSP implementation); Kinetics; Chemistry; Protein folding; Denaturation (fissile materials); Force spectroscopy; Molecule; Biophysics; Phi value analysis; Downhill folding; Native state; Crystallography; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005886612,0.0003827248,0.0003315333,0.0003073185,0.000306658,0.0005497694,0.0005197854,0.0007083464,0.0007750848],"category_scores_gemma":[0.001675524,0.0002714865,0.0001568357,0.0002354766,0.0005580215,0.001042695,0.0002412852,0.0007085814,0.00019835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003689528,"about_ca_system_score_gemma":0.0002174474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004818116,"about_ca_topic_score_gemma":0.0008069209,"domain_scores_codex":[0.9997172,0.00004339453,0.00001662167,0.00007645771,0.0001167604,0.00002953819],"domain_scores_gemma":[0.9994447,0.000280012,0.00007912864,0.00008301995,0.00006501623,0.00004814054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001132205,0.00007061725,0.001047258,0.00005398326,0.00001383937,0.00003985668,0.00007062076,0.0009637628,0.9887241,0.0006707836,0.0001580386,0.00807402],"study_design_scores_gemma":[0.00002419685,0.0001756386,0.007810737,0.000007720277,0.00001534191,0.0001788809,0.00004234942,0.05030646,0.9393454,0.0009590366,0.001094574,0.00003971961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9638364,0.0003840138,0.03402898,0.0002099906,0.0001033604,0.00003791534,0.000232808,0.0002238282,0.0009427673],"genre_scores_gemma":[0.9804195,0.0004713576,0.01796325,0.0001058676,0.00004175194,0.000045111,0.0001683374,0.00003757498,0.0007474487],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0007750848,"threshold_uncertainty_score":0.003113151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009962648850716769,"score_gpt":0.2658649885620802,"score_spread":0.2559023397113634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}