{"id":"W2079747871","doi":"10.1007/s13659-015-0057-3","title":"Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides","year":2015,"lang":"en","type":"article","venue":"Natural Products and Bioprospecting","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Chemistry; Cytotoxicity; Etoposide; Triazole; Moiety; MTT assay; Stereochemistry; Click chemistry; Cisplatin; Glycoside; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004274361,0.0001872773,0.0002647475,0.00004282626,0.0000990662,0.00004115139,0.00008830074,0.000118577,0.00000135014],"category_scores_gemma":[0.0005699053,0.0001395695,0.00003767902,0.000119393,0.0001822331,0.00001930611,0.0001390606,0.0001274882,5.448699e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001340616,"about_ca_system_score_gemma":0.00004375267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001364958,"about_ca_topic_score_gemma":0.00003113457,"domain_scores_codex":[0.998918,0.00003974857,0.0001637202,0.0004888552,0.000157875,0.0002318117],"domain_scores_gemma":[0.9993874,0.00003843789,0.0001499445,0.0002067186,0.0001360197,0.00008140878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188898,0.00005107247,0.008666723,0.00006090699,0.00004325055,0.000002097593,0.00004112988,3.553051e-7,0.9698617,0.00005123184,0.00005807507,0.02094457],"study_design_scores_gemma":[0.0002618893,0.0001383123,0.02169887,0.00003806323,0.0000286685,0.00005119215,0.00009855394,0.00004994911,0.9769153,0.000063717,0.0004503671,0.0002051126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959349,0.003001694,0.000009994216,0.0004151608,0.0001656884,0.0002003406,0.00002627859,0.00001608542,0.0002298362],"genre_scores_gemma":[0.9982721,0.0002826262,0.0009489869,0.00002805489,0.0003171388,0.000006342602,0.00000401646,0.00001405904,0.0001266439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02073946,"threshold_uncertainty_score":0.569148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887533131393762,"score_gpt":0.2440404843307641,"score_spread":0.2251651530168265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}