{"id":"W2079747871","doi":"10.1007/s13659-015-0057-3","title":"Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides","year":2015,"lang":"en","type":"article","venue":"Natural Products and Bioprospecting","topic":"Plant-derived Lignans Synthesis and Bioactivity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"Institute of Botany, Chinese Academy of Sciences; Kunming Institute of Botany, Chinese Academy of Sciences; State Key Laboratory of Phytochemistry and Plant Resources in West China; Chinese Academy of Sciences","keywords":"Podophyllotoxin; Chemistry; Cytotoxicity; Etoposide; Triazole; Moiety; MTT assay; Stereochemistry; Click chemistry; Cisplatin; Glycoside; Combinatorial chemistry; Biochemistry; In vitro; Organic chemistry; Biology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006870663,0.0002997549,0.0002235295,0.0002374179,0.00008858926,0.000173331,0.0001359097,0.0001641336,0.001201582],"category_scores_gemma":[0.00009224856,0.0000906287,0.0002291813,0.0002979994,0.00008616014,0.0001969436,0.0001447779,0.0002645434,0.0003143972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001433133,"about_ca_system_score_gemma":0.0001453087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001968692,"about_ca_topic_score_gemma":0.0004353074,"domain_scores_codex":[0.9999673,0.000004468584,0.000004884522,0.000005981674,0.00000800893,0.00000935657],"domain_scores_gemma":[0.9999496,0.000004991024,0.00001909434,0.000005478003,0.000007988582,0.00001288114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006606988,0.0000476893,0.0002056794,0.00006992507,0.000006939027,0.0001619777,0.00001725554,0.0003250746,0.9939116,0.0001279541,0.00003190263,0.005027857],"study_design_scores_gemma":[0.00005528579,0.001499304,0.006339956,0.00001553554,0.00004775319,0.0007158134,0.00002808224,0.0009367475,0.9856991,0.000113599,0.004537146,0.00001172678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988627,0.002431092,0.005539547,0.00008161763,0.00002406059,0.00008399878,0.0004437185,0.00008181089,0.002687027],"genre_scores_gemma":[0.9902509,0.002545848,0.004411633,0.00004256104,0.00001012487,0.00003865814,0.0006160501,0.00001069626,0.00207351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001201582,"threshold_uncertainty_score":0.004019678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887533131393762,"score_gpt":0.2440404843307641,"score_spread":0.2251651530168265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}