{"id":"W2079756400","doi":"10.1038/tpj.2015.20","title":"Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing","year":2015,"lang":"en","type":"article","venue":"The Pharmacogenomics Journal","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Transcriptome; Gene; Glucuronidation; Exon; Biology; Glucuronosyltransferase; Alternative splicing; Exon skipping; Human genome; RNA splicing; Computational biology; RNA; Genome; Genetics; RNA-Seq; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725288,0.000289039,0.0002930014,0.0004626523,0.0002632993,0.0007234328,0.0001746133,0.0002758708,0.0008131875],"category_scores_gemma":[0.0004885035,0.0001800797,0.0003874887,0.000409553,0.0002196652,0.0003006912,0.0002406429,0.0006099464,0.0003101669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370858,"about_ca_system_score_gemma":0.0004540064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009355404,"about_ca_topic_score_gemma":0.003245188,"domain_scores_codex":[0.9998387,0.00002560296,0.000007324144,0.00006616172,0.00003615268,0.00002608864],"domain_scores_gemma":[0.9997695,0.00009661805,0.00005134086,0.00001990313,0.00004269894,0.00001994324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007786822,0.00001028353,0.004709723,0.00007780839,0.00003223203,0.0000613873,0.00006249797,0.0006141954,0.9835576,0.0005577714,0.0001638341,0.01007487],"study_design_scores_gemma":[0.00004537615,0.0007055519,0.3728155,0.0001371197,0.0004560702,0.001216311,0.0009309467,0.05264484,0.5274847,0.007996083,0.03547884,0.00008852917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9272286,0.005240035,0.05444713,0.0008635572,0.00009441801,0.00008096721,0.007387869,0.0003235407,0.004333867],"genre_scores_gemma":[0.953262,0.002964112,0.03372558,0.0007847905,0.00008250532,0.00008662182,0.005766476,0.0001680389,0.003159971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009355404,"threshold_uncertainty_score":0.002720356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1554853162253451,"score_gpt":0.3919667441657512,"score_spread":0.2364814279404061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}