{"id":"W2079778211","doi":"10.1248/cpb.56.374","title":"Endodesmiadiol, a Friedelane Triterpenoid, and Other Antiplasmodial Compounds from Endodesmia calophylloides","year":2008,"lang":"en","type":"article","venue":"Chemical and Pharmaceutical Bulletin","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut Universitaire de France; Agence Universitaire de la Francophonie","keywords":"Friedelin; Chemistry; Plasmodium falciparum; Stereochemistry; Triterpenoid; Chloroquine; IC50; Traditional medicine; Terpene; Terpenoid; Ethyl acetate; Pharmacognosy; Biological activity; In vitro; Organic chemistry; Biochemistry; Malaria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004207979,0.0003469076,0.0001807539,0.000307507,0.0001084731,0.00011511,0.00008704967,0.0001762331,0.0007291534],"category_scores_gemma":[0.00008260989,0.00008125917,0.0001429624,0.0002399016,0.0001202582,0.0002021352,0.0001356842,0.0002318659,0.0001496582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129288,"about_ca_system_score_gemma":0.0001616586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004836782,"about_ca_topic_score_gemma":0.001198188,"domain_scores_codex":[0.9999815,0.000002284954,0.00000183934,0.000004581347,0.000004693301,0.000005132832],"domain_scores_gemma":[0.9999551,0.000008794186,0.000009972344,0.000004647334,0.000007996934,0.00001355669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000146577,0.00001920506,0.000597777,0.00009450295,0.000006563027,0.0001459775,0.00001933395,0.00005474045,0.9923671,0.00003925641,0.00002574754,0.006483341],"study_design_scores_gemma":[0.0001302375,0.001099166,0.0488523,0.00003279817,0.00008432321,0.001566719,0.0001021984,0.0002721997,0.9341567,0.000140367,0.01354809,0.0000148777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98864,0.006260895,0.001588142,0.00007372952,0.00001502345,0.00005052445,0.0007266836,0.00002300835,0.002622121],"genre_scores_gemma":[0.9883764,0.003267168,0.003494845,0.000106415,0.00001942646,0.00003216392,0.002268911,0.000007890456,0.002426851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007291534,"threshold_uncertainty_score":0.002439201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02402982959863369,"score_gpt":0.2524505654730093,"score_spread":0.2284207358743756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}