{"id":"W2079778211","doi":"10.1248/cpb.56.374","title":"Endodesmiadiol, a Friedelane Triterpenoid, and Other Antiplasmodial Compounds from Endodesmia calophylloides","year":2008,"lang":"en","type":"article","venue":"Chemical and Pharmaceutical Bulletin","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut Universitaire de France; Agence Universitaire de la Francophonie","keywords":"Friedelin; Chemistry; Plasmodium falciparum; Stereochemistry; Triterpenoid; Chloroquine; IC50; Traditional medicine; Terpene; Terpenoid; Ethyl acetate; Pharmacognosy; Biological activity; In vitro; Organic chemistry; Biochemistry; Malaria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009216422,0.0002454366,0.0002766894,0.00002002648,0.0001424233,0.00003137562,0.0001257267,0.0002204432,0.0002467525],"category_scores_gemma":[0.00008713955,0.0002049792,0.0000772442,0.00003871504,0.0005445413,0.000003674091,0.0001611692,0.0002590091,0.00001925436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000768535,"about_ca_system_score_gemma":0.00001627689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007367791,"about_ca_topic_score_gemma":9.291151e-7,"domain_scores_codex":[0.9987402,0.0000639053,0.0002099315,0.0005395011,0.0001237847,0.000322707],"domain_scores_gemma":[0.9993802,0.0001260073,0.00003950069,0.0001715384,0.000025453,0.0002573114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006368142,0.00007488469,0.00255309,0.00002049764,0.00007189233,0.0000186198,0.00004171067,1.805195e-7,0.9875737,0.00004466211,0.006183775,0.002780104],"study_design_scores_gemma":[0.0009282456,0.00005359628,0.0002198563,0.000009452207,0.0000233433,0.000138721,0.00001275523,0.00003736567,0.6743134,0.00007872629,0.3239493,0.0002351763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928181,0.004293146,0.00003937114,0.001137315,0.00008206884,0.0001266287,0.0001335498,0.00002290083,0.001346908],"genre_scores_gemma":[0.9951606,0.00104282,0.001030756,0.001761433,0.0005535595,0.00001161199,0.00006039532,0.00002462558,0.0003542445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3177656,"threshold_uncertainty_score":0.8358811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02402982959863369,"score_gpt":0.2524505654730093,"score_spread":0.2284207358743756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}