{"id":"W2079780498","doi":"10.1016/j.immuni.2006.04.012","title":"Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated Pathway","year":2006,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Robarts Clinical Trials; Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Biology; Superantigen; T-cell receptor; Cell biology; Signal transduction; MAPK/ERK pathway; ZAP70; Heterotrimeric G protein; T cell; Phosphorylation; G protein; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0009096761,0.0003249761,0.0004155043,0.0002043589,0.0004181992,0.00006489082,0.0003777758,0.000485759,0.001940315],"category_scores_gemma":[0.0001683969,0.0003268518,0.0001197322,0.0002230954,0.0001053503,0.0003570345,0.0001360397,0.0008250308,0.0009919208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001736322,"about_ca_system_score_gemma":0.0001481972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003850123,"about_ca_topic_score_gemma":0.000163716,"domain_scores_codex":[0.997064,0.001101933,0.0007352031,0.0003409078,0.00009586363,0.000662079],"domain_scores_gemma":[0.9987321,0.0004475486,0.0002605938,0.0004353139,0.0001004266,0.00002403338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000608899,0.0003392478,0.001160183,0.00001977607,0.00004789314,0.000006476458,0.0006058991,0.00001799057,0.9951298,0.00002245737,0.001077783,0.0009636268],"study_design_scores_gemma":[0.003022226,0.0001188293,0.00204079,0.0000487371,0.000011881,0.00001365958,0.0005915936,0.000007287462,0.975127,0.00002465271,0.01863213,0.0003611808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951187,0.00124992,0.000097621,0.0001028828,0.0009766364,0.0003770841,0.0001233136,0.0001392009,0.001814665],"genre_scores_gemma":[0.9945714,0.00006904612,0.00004560915,0.00004330779,0.0000838466,0.00004032043,0.002117393,0.00004117066,0.002987906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02000274,"threshold_uncertainty_score":0.9999183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007559912364664269,"score_gpt":0.2010912754486004,"score_spread":0.1935313630839361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}