{"id":"W2079780498","doi":"10.1016/j.immuni.2006.04.012","title":"Bacterial Superantigens Bypass Lck-Dependent T Cell Receptor Signaling by Activating a Gα11-Dependent, PLC-β-Mediated Pathway","year":2006,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lawson Health Research Institute; Robarts Clinical Trials; Western University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","keywords":"Biology; Superantigen; T-cell receptor; Cell biology; Signal transduction; MAPK/ERK pathway; ZAP70; Heterotrimeric G protein; T cell; Phosphorylation; G protein; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002137538,0.0005243619,0.0002281997,0.0002719502,0.0001900129,0.0005723801,0.0001969599,0.0003049027,0.002541396],"category_scores_gemma":[0.0002698661,0.0001882239,0.0003141719,0.0001511601,0.0003098439,0.0004412296,0.0004002948,0.001268003,0.001307647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004839498,"about_ca_system_score_gemma":0.0003970687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003689044,"about_ca_topic_score_gemma":0.0004855729,"domain_scores_codex":[0.9997227,0.00004598204,0.00001822311,0.00002635831,0.00005216349,0.000134605],"domain_scores_gemma":[0.9998071,0.00003926121,0.00005688226,0.00003259347,0.00002009411,0.0000441573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006701495,0.00008635937,0.0004088896,0.00007521961,0.000009714735,0.0001442385,0.00002150729,0.00009583747,0.9927514,0.0005230349,0.0002331058,0.004980488],"study_design_scores_gemma":[0.0001624711,0.0004792383,0.007140122,0.00001911144,0.00002013516,0.0005238054,0.0000649808,0.001082576,0.9846879,0.0003843732,0.005428358,0.000006952231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856408,0.002264975,0.005349777,0.0005212415,0.0001259509,0.00007044344,0.0003503028,0.0003052774,0.005371317],"genre_scores_gemma":[0.9929309,0.001303032,0.001977885,0.0002219738,0.00004209348,0.00005014997,0.0003737994,0.00003608961,0.003064065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002541396,"threshold_uncertainty_score":0.008501828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007559912364664269,"score_gpt":0.2010912754486004,"score_spread":0.1935313630839361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}