{"id":"W2079791093","doi":"10.1128/aac.48.11.4189-4194.2004","title":"Differential Maintenance of the M184V Substitution in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 by Various Nucleoside Antiretroviral Agents in Tissue Culture","year":2004,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Resistance mutation; Didanosine; Zalcitabine; Virology; Reverse transcriptase; Abacavir; Lamivudine; Biology; Reverse-transcriptase inhibitor; Nucleoside analogue; Nucleoside; Virus; Viral load; Antiretroviral therapy; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003062705,0.0003207141,0.0004212182,0.0002065889,0.0002366883,0.0003759275,0.0005363814,0.0002832961,0.000755981],"category_scores_gemma":[0.000309796,0.0001969349,0.0003506154,0.0002602527,0.000142688,0.0002395114,0.0002624694,0.0008148491,0.0005112808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003776966,"about_ca_system_score_gemma":0.0003220421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001726638,"about_ca_topic_score_gemma":0.002887112,"domain_scores_codex":[0.9997069,0.00007994413,0.00004777786,0.00005484862,0.00007222088,0.00003826379],"domain_scores_gemma":[0.9997697,0.00007782591,0.00003636047,0.0000391945,0.00005352794,0.00002337756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001118488,0.00006611211,0.000239152,0.00004910004,0.000009720357,0.00006255585,0.00004069291,0.0001531846,0.9970445,0.00009166581,0.00009660082,0.002034914],"study_design_scores_gemma":[0.00003091395,0.001010121,0.002410757,0.0000170573,0.00004545821,0.0003604255,0.00003650876,0.001460955,0.9899791,0.00003652238,0.004602684,0.000009488253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983466,0.006802921,0.005106674,0.0001667923,0.0001112423,0.0001587452,0.001149994,0.00006402513,0.002973661],"genre_scores_gemma":[0.9675107,0.004573342,0.01784939,0.0001390843,0.00005465762,0.0002029255,0.004376051,0.00004104753,0.005252844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001726638,"threshold_uncertainty_score":0.003433168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275209272417905,"score_gpt":0.2628045841648711,"score_spread":0.2500524914406921,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}