{"id":"W2079794722","doi":"10.1016/j.neuropharm.2008.07.024","title":"Role of orexin/hypocretin and CRF in the formation of drug-dependent synaptic plasticity in the mesolimbic system","year":2008,"lang":"en","type":"review","venue":"Neuropharmacology","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ventral tegmental area; Neuroscience; Glutamatergic; Synaptic plasticity; Long-term potentiation; Metaplasticity; Excitatory postsynaptic potential; Orexin; Neurotransmission; Addiction; Dopamine; Psychology; Biology; Neuropeptide; Glutamate receptor; Inhibitory postsynaptic potential; Dopaminergic","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004678091,0.0002597145,0.0009282405,0.000417117,0.00008496839,0.00001754064,0.001041512,0.0001431858,0.0000148568],"category_scores_gemma":[0.0005475748,0.000149224,0.0001262672,0.000766342,0.00034479,0.00008016397,0.0001907707,0.0008817208,0.00001614637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006299795,"about_ca_system_score_gemma":0.0001291219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004572494,"about_ca_topic_score_gemma":0.00001370122,"domain_scores_codex":[0.9933317,0.00448672,0.0008492105,0.0003936885,0.0005560434,0.0003826642],"domain_scores_gemma":[0.994258,0.004970232,0.0004324121,0.0002633274,0.00003777854,0.00003826353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009072641,0.002657262,0.0002107345,0.07399151,0.0001329018,0.004176776,0.01252172,0.0003389786,0.02974442,0.006464714,0.001135997,0.8677177],"study_design_scores_gemma":[0.0252067,0.006527832,0.005051308,0.02579535,0.004917973,0.04058361,0.01129836,0.04351773,0.0828054,0.0005516404,0.7483695,0.00537463],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2194354,0.7738925,0.000008311744,0.0001174787,0.0003853895,0.003876439,0.00009294441,0.00002864886,0.002162962],"genre_scores_gemma":[0.4774497,0.522264,6.427937e-7,0.00006794173,0.000026559,0.000173162,0.000001399467,0.00001297753,0.000003661626],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8623431,"threshold_uncertainty_score":0.6085179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05658603254999291,"score_gpt":0.3421229497054025,"score_spread":0.2855369171554096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}