{"id":"W2079795230","doi":"10.1042/bj20141291","title":"Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax","year":2015,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Cardiolipin; Cell biology; Apoptosis; Bacterial outer membrane; Mitochondrion; Mediator; Activator (genetics); Inner mitochondrial membrane; Liposome; Membrane; Biology; Chemistry; Cell; Programmed cell death; Membrane protein; Biochemistry; Receptor; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762005,0.0001076785,0.00011263,0.00003272452,0.00004314171,0.00002023401,0.00006197343,0.000146065,0.000005636349],"category_scores_gemma":[0.000227624,0.00008524634,0.00004433224,0.00005710821,0.00004114031,0.000005553418,0.00003159663,0.00008349142,0.000001095987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002240571,"about_ca_system_score_gemma":0.00003977634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001935432,"about_ca_topic_score_gemma":1.744218e-7,"domain_scores_codex":[0.9992995,0.0000486952,0.0001806284,0.0001723309,0.0001807444,0.0001181312],"domain_scores_gemma":[0.9995065,0.00001649607,0.0001247188,0.0001052371,0.000111791,0.0001352225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001379325,0.00006449498,0.0002751509,0.00003824862,0.00001517768,3.831553e-7,0.00001990093,0.00001118827,0.9932311,0.00004531249,0.001662057,0.004499058],"study_design_scores_gemma":[0.0007519977,0.000498843,0.0006904696,0.00005275793,0.00001719401,0.00003125554,0.00001863864,0.0002558166,0.9958811,0.0001736465,0.001523916,0.0001044059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960543,0.0002554946,0.003147583,0.0001478474,0.0001371686,0.0001292059,0.000003458235,0.000005156151,0.0001197906],"genre_scores_gemma":[0.998783,0.00008884742,0.000446809,0.000048954,0.0004173444,0.000003496065,0.000103022,0.0000133184,0.00009520787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004394652,"threshold_uncertainty_score":0.3476245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00978084477121918,"score_gpt":0.234200798222477,"score_spread":0.2244199534512578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}