{"id":"W2079799953","doi":"10.1016/j.bcp.2014.05.023","title":"High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)","year":2014,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; University of New South Wales; Cancer Institute NSW","keywords":"Abcg2; ATP-binding cassette transporter; ABCC1; Transporter; Multiple drug resistance; Pharmacology; P-glycoprotein; Biology; Computational biology; Multidrug Resistance-Associated Proteins; Biochemistry; Chemistry; Drug resistance; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003272285,0.0002944917,0.0006195319,0.0001188531,0.00010139,0.00001035158,0.0001498842,0.0002568161,0.00008555175],"category_scores_gemma":[0.00009373559,0.0002588249,0.0001234398,0.0002560905,0.0004265714,0.00008368823,0.00007340773,0.0003966752,0.0000146741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006037029,"about_ca_system_score_gemma":0.00007096883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009085588,"about_ca_topic_score_gemma":0.000008391096,"domain_scores_codex":[0.9980171,0.00009851807,0.0005201143,0.0005851833,0.000328653,0.0004504579],"domain_scores_gemma":[0.9990531,0.0001014403,0.0002185874,0.0002031248,0.00017675,0.0002470515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00130721,0.0002111607,0.0002285322,0.0003950001,0.0001388244,0.00004015423,0.0001906073,0.000002069835,0.9820869,0.000638901,0.0145576,0.0002030655],"study_design_scores_gemma":[0.003435429,0.0002076127,0.001440969,0.0002273613,0.0002054709,0.00001295962,0.00006893135,0.00003919729,0.98759,0.001029607,0.005489902,0.0002526066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947191,0.0009426503,0.0005993588,0.001780367,0.0003776242,0.0008064798,0.00001695084,0.0001081831,0.0006492218],"genre_scores_gemma":[0.9891151,0.00007366984,0.007230543,0.0003029021,0.0005235394,0.00008642986,0.00003449314,0.00004329533,0.002589987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0090677,"threshold_uncertainty_score":0.9999864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007190211322087901,"score_gpt":0.2589112337161687,"score_spread":0.2517210223940808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}