{"id":"W2079809618","doi":"10.1038/mt.2011.298","title":"Cell Fate Control Gene Therapy Based on Engineered Variants of Human Deoxycytidine Kinase","year":2012,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Suicide gene; Deoxycytidine kinase; Thymidine kinase; Biology; Genetic enhancement; Cell biology; Cancer research; Gene; Genetics; Deoxycytidine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690593,0.0003752706,0.00022119,0.0002115002,0.0001179644,0.000382616,0.0002434556,0.0003591352,0.0004429439],"category_scores_gemma":[0.0001431852,0.0001525244,0.0002106054,0.0001634443,0.0003173669,0.0002265674,0.0002093501,0.0005205751,0.0002324635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004268086,"about_ca_system_score_gemma":0.0002310267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003699428,"about_ca_topic_score_gemma":0.0004345854,"domain_scores_codex":[0.9998271,0.00002290625,0.00001618841,0.00004743272,0.00005767767,0.00002873576],"domain_scores_gemma":[0.9999042,0.00002009577,0.00003515092,0.00001868718,0.000009337384,0.00001253698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002299951,0.000008926367,0.00006797461,0.00002313909,0.000002434057,0.00002904631,0.00001070448,0.0001558069,0.9967667,0.0005165299,0.00003438385,0.002361362],"study_design_scores_gemma":[0.000008662559,0.00009555111,0.0002056783,0.000002977633,0.000005974878,0.0002280541,0.000003135556,0.0007000004,0.9944162,0.00006006319,0.004269837,0.000003869967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8795496,0.006568832,0.1058559,0.000240061,0.0001945038,0.0002851804,0.0005744497,0.0005902111,0.006141352],"genre_scores_gemma":[0.9572065,0.002467264,0.036319,0.0000853841,0.0000269544,0.0001066849,0.0003223215,0.00006296417,0.003402902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004429439,"threshold_uncertainty_score":0.003096759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471597940835443,"score_gpt":0.2928219588182776,"score_spread":0.2681059794099232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}