{"id":"W2079809618","doi":"10.1038/mt.2011.298","title":"Cell Fate Control Gene Therapy Based on Engineered Variants of Human Deoxycytidine Kinase","year":2012,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Suicide gene; Deoxycytidine kinase; Thymidine kinase; Biology; Genetic enhancement; Cell biology; Cancer research; Gene; Genetics; Deoxycytidine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006741741,0.0003691546,0.0005953382,0.0003254988,0.00007312102,0.00001945475,0.0002509717,0.0001838979,0.003347879],"category_scores_gemma":[0.00002445136,0.0003081632,0.0003374592,0.0003996105,0.00008983818,0.00005515819,0.00001523122,0.0003343801,0.00005482309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009942169,"about_ca_system_score_gemma":0.00008901631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005619978,"about_ca_topic_score_gemma":4.093552e-7,"domain_scores_codex":[0.9975185,0.0002671866,0.0003914422,0.0003536058,0.0007612738,0.0007079772],"domain_scores_gemma":[0.9982461,0.0001037828,0.0001194971,0.001004137,0.0001761131,0.0003504121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002641828,0.001524563,0.002159797,0.00002561854,0.000228539,0.0001168345,0.0001630575,0.000174968,0.983998,0.00008905616,0.0001307122,0.00874702],"study_design_scores_gemma":[0.01868389,0.002281488,0.00856682,0.0000360656,0.00003160658,0.00001268053,0.00001293403,0.001071175,0.9621662,0.00003702127,0.006823393,0.0002766978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842358,0.004078084,0.006215406,0.000417995,0.0001373685,0.001322289,0.00002394108,0.00008945688,0.003479625],"genre_scores_gemma":[0.9953393,0.0004951551,0.000471932,0.00211041,0.0002328227,0.00008986313,0.00006659458,0.0001406838,0.001053259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02183178,"threshold_uncertainty_score":0.9999371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471597940835443,"score_gpt":0.2928219588182776,"score_spread":0.2681059794099232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}