{"id":"W2079849140","doi":"10.1074/jbc.m202222200","title":"Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-κB Activation Induced by Phorbol Ester","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; National Institute of General Medical Sciences; Ariad Pharmaceuticals","keywords":"Protein kinase C; Phorbol ester; ASK1; MAP kinase kinase kinase; Chemistry; BCL10; Mitogen-activated protein kinase kinase; Protein kinase R; MAP2K7; Cyclin-dependent kinase 9; IκB kinase; Kinase; Cyclin-dependent kinase 2; Phorbol; c-Raf; Cancer research; Cell biology; NF-κB; Signal transduction; Protein kinase A; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004797385,0.0003156018,0.000373771,0.00003353182,0.00009029479,0.00004992135,0.000425444,0.0007511295,0.0003631986],"category_scores_gemma":[0.001040022,0.0002426579,0.000247553,0.0001341608,0.00009735082,0.00001374248,0.0001214366,0.000547252,0.00001387639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031659,"about_ca_system_score_gemma":0.00005726424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004570522,"about_ca_topic_score_gemma":6.393144e-7,"domain_scores_codex":[0.9980541,0.000124173,0.0006513845,0.0003878475,0.0003798664,0.000402617],"domain_scores_gemma":[0.998434,0.0000466189,0.0007124385,0.0002708208,0.0002767727,0.0002593362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384897,0.0004877565,0.0006308298,0.00001972202,0.00009567171,0.00003484659,0.00002954421,0.000006623055,0.9953533,0.000001039521,0.002355581,0.000846601],"study_design_scores_gemma":[0.001239572,0.0005851854,0.000281338,0.00007440706,0.00002258503,0.00004121863,0.00006662367,0.00002354804,0.9948913,0.00006164177,0.00240286,0.0003096983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981158,0.0006173408,0.0001103995,0.0003689012,0.00009148299,0.000166082,0.00003456496,0.0000209279,0.0004745109],"genre_scores_gemma":[0.9983799,0.00009535949,0.0001728913,0.0002531978,0.0004924618,0.00001738156,0.0001168467,0.00002660176,0.0004453313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101083,"threshold_uncertainty_score":0.98953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02688309631820378,"score_gpt":0.2390247222009328,"score_spread":0.212141625882729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}