{"id":"W2079853302","doi":"10.1053/j.gastro.2010.09.004","title":"Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches","year":2010,"lang":"en","type":"review","venue":"Gastroenterology","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":282,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Pathogenesis; Immune system; Disease; Liver injury; Liver disease; Cholestasis; Autoimmunity; Immunology; Medicine; Bile acid; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000598304,0.001258078,0.002097029,0.002124949,0.0002789124,0.001147497,0.0009839737,0.00122803,0.003248557],"category_scores_gemma":[0.000565225,0.0003606775,0.000471459,0.002135477,0.0006177503,0.001472919,0.0008102545,0.001888774,0.001935415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005996844,"about_ca_system_score_gemma":0.00119162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009647884,"about_ca_topic_score_gemma":0.00195679,"domain_scores_codex":[0.9998388,0.0000275891,0.0000271404,0.00002599985,0.00006054752,0.00001983656],"domain_scores_gemma":[0.9997903,0.00008407258,0.00003796462,0.000007730845,0.00005725869,0.00002273748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001844692,0.0001292834,0.0002096059,0.01562632,0.00009837158,0.0002715707,0.00004771787,0.000469431,0.002470393,0.002891422,0.0277251,0.9498762],"study_design_scores_gemma":[0.000062842,0.0001502829,0.001282379,0.005126846,0.0002628272,0.00177894,0.00009839677,0.0001825457,0.0006783684,0.002909628,0.9874367,0.00003026407],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007171364,0.9989421,0.00008548918,0.0001723835,0.0001574279,0.000003862318,0.00001039632,0.000004231797,0.0005525258],"genre_scores_gemma":[0.0004430397,0.9986697,0.0001618424,0.0001313925,0.0001823914,0.000005405819,0.00001938365,6.482539e-7,0.0003862229],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003248557,"threshold_uncertainty_score":0.01086748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08280087464167159,"score_gpt":0.2986416957414587,"score_spread":0.2158408210997871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}