{"id":"W2079889598","doi":"10.1073/pnas.0407444102","title":"β-Arrestins bind and decrease cell-surface abundance of the Na + /H + exchanger NHE5 isoform","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; McGill University; University of British Columbia","funders":"","keywords":"Clathrin; Endocytosis; Cytoplasm; Signal transducing adaptor protein; Gene isoform; Internalization; Cell biology; Biology; Complementary DNA; PDZ domain; Membrane protein; Fusion protein; Vesicle; cDNA library; Clathrin adaptor proteins; Transport protein; Molecular biology; Immunoprecipitation; Cell membrane; Receptor; Signal transduction; Biochemistry; Cell; Membrane; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005638576,0.0003028486,0.0002127851,0.0001288294,0.00008349652,0.0002317993,0.00009988106,0.0001753069,0.001543564],"category_scores_gemma":[0.00007979109,0.000123364,0.0001852148,0.00008551873,0.0001153955,0.0001008184,0.0001134879,0.0004768394,0.0005764648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184711,"about_ca_system_score_gemma":0.0001223492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005472722,"about_ca_topic_score_gemma":0.0008832339,"domain_scores_codex":[0.9999202,0.000009608926,0.000006812664,0.00001454547,0.00001895374,0.00002980179],"domain_scores_gemma":[0.9999452,0.00001005263,0.00001388375,0.000005507512,0.000006968392,0.00001856027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001440551,0.00004253618,0.0001780004,0.00002714905,0.00001156281,0.00002019689,0.000005339825,0.000026141,0.9980568,0.00003867596,0.0001069013,0.001342668],"study_design_scores_gemma":[0.00002785712,0.000278993,0.01133317,0.000006115185,0.00002174164,0.0001774976,0.00002894409,0.0006832233,0.9837883,0.00002238692,0.003629096,0.00000267187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934393,0.00267171,0.000917265,0.0001373642,0.00003316768,0.00001820499,0.0004610607,0.0001064819,0.002215384],"genre_scores_gemma":[0.9877219,0.002249292,0.001284052,0.0001837079,0.00001936642,0.0000497959,0.001730868,0.00003630743,0.006724916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001543564,"threshold_uncertainty_score":0.00516367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998201631583758,"score_gpt":0.2617099424976024,"score_spread":0.2417279261817649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}