{"id":"W2079903691","doi":"10.1089/brain.2012.0137","title":"Breakdown of Brain Connectivity Between Normal Aging and Alzheimer's Disease: A Structural <i>k</i> -Core Network Analysis","year":2013,"lang":"en","type":"article","venue":"Brain Connectivity","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":182,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Alzheimer Immunotherapy Research And Development; Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; University of California, San Diego; National Institutes of Health; Genentech; IXICO; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; F. Hoffmann-La Roche; Medpace; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Synarc; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Neuroscience; Connectome; Diffusion MRI; Tractography; Connectomics; Human brain; Psychology; Alzheimer's disease; Disease; Cognition; Cognitive decline; Medicine; Functional connectivity; Dementia; Pathology; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001275895,0.0006604781,0.001260441,0.0004180309,0.0009008045,0.0001804489,0.000479919,0.0001788801,0.000255045],"category_scores_gemma":[0.01596706,0.0006398175,0.0004824324,0.002283191,0.0009105807,0.001180515,0.0007322617,0.0005445361,0.00002793739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009910707,"about_ca_system_score_gemma":0.0001429827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355337,"about_ca_topic_score_gemma":0.0007051817,"domain_scores_codex":[0.994851,0.0009932247,0.0006442143,0.001675537,0.0008062172,0.001029817],"domain_scores_gemma":[0.9603217,0.03754777,0.0005187016,0.000897377,0.0002358568,0.0004786453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001697371,0.0001256568,0.95259,0.00009243812,0.001322224,0.00002806093,0.0004667039,0.002567378,0.01272479,0.006217369,0.009393791,0.01430188],"study_design_scores_gemma":[0.0009907183,0.0001710155,0.9704905,0.00004103856,0.0007544743,0.000020485,0.00007843001,0.008911141,0.005203676,0.01158616,0.0009646039,0.0007878128],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770788,0.0004392481,0.001570855,0.01820077,0.0003303585,0.00105062,0.0003148186,0.0002814966,0.0007330586],"genre_scores_gemma":[0.9946002,0.00001027468,0.000219794,0.004323348,0.0005144309,0.0001348876,0.00002298817,0.00005823407,0.0001158392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03655454,"threshold_uncertainty_score":0.9996053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03256733296774734,"score_gpt":0.2743241322167734,"score_spread":0.2417567992490261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}