{"id":"W2079932486","doi":"10.1016/s0022-2836(02)00164-x","title":"Design of Peptide-based Inhibitors of Human Islet Amyloid Polypeptide Fibrillogenesis","year":2002,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; W. Garfield Weston Foundation; Garfield Weston Foundation","keywords":"Chemistry; Fibrillogenesis; Peptide; Fibril; Circular dichroism; Amylin; Random coil; Amyloid (mycology); Tripeptide; Peptide sequence; Biochemistry; Islet; Biophysics; Biology; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003265674,0.0006819427,0.0004860598,0.0002794874,0.0002299174,0.0005307141,0.0007073396,0.0004159473,0.001253893],"category_scores_gemma":[0.0002588895,0.0003554173,0.0003223824,0.000141117,0.0001835247,0.0002873199,0.0002490954,0.000946874,0.0004337117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004724105,"about_ca_system_score_gemma":0.0002413549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004538342,"about_ca_topic_score_gemma":0.0009146952,"domain_scores_codex":[0.9998871,0.00001744929,0.00001039421,0.00001987967,0.00002631803,0.00003879477],"domain_scores_gemma":[0.9999244,0.00001618581,0.00001931658,0.000004309577,0.00001387578,0.00002189039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001099202,0.0005870102,0.0003248407,0.000298156,0.00009135871,0.0006037605,0.00006462377,0.007531404,0.9616031,0.002059739,0.001023183,0.02471362],"study_design_scores_gemma":[0.0008812209,0.00210524,0.0005485432,0.00003741133,0.0001095463,0.0007534625,0.00002950445,0.01110315,0.9655761,0.0003775776,0.01844244,0.00003573013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9069669,0.02059566,0.05850026,0.0006421061,0.0005581239,0.001065938,0.001085152,0.0005292685,0.01005671],"genre_scores_gemma":[0.9669406,0.009450612,0.0169217,0.0003716857,0.00006012338,0.0003568542,0.001074302,0.00004187002,0.004782144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253893,"threshold_uncertainty_score":0.004194736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03610078060949436,"score_gpt":0.3172432289146488,"score_spread":0.2811424483051544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}