{"id":"W2079952218","doi":"10.1016/j.bmc.2012.11.034","title":"Biocatalytic synthesis, structural elucidation, antioxidant capacity and tyrosinase inhibition activity of long chain fatty acid acylated derivatives of phloridzin and isoquercitrin","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Atlantic Canada Opportunities Agency; Universities Space Research Association; Acadia University","keywords":"Chemistry; Candida antarctica; Tyrosinase; Lipase; Acylation; Antioxidant; Acetone; Organic chemistry; Fatty acid; Enzyme; Stereochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000254669,0.0001640191,0.0002222683,0.00002823434,0.0000523491,0.000006240657,0.00005820491,0.0001566205,0.00003151258],"category_scores_gemma":[0.0002635476,0.0001487444,0.00003043326,0.0001029758,0.0002824277,0.00002030042,0.00006336116,0.00008255425,3.035099e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002097204,"about_ca_system_score_gemma":0.00003989781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003889934,"about_ca_topic_score_gemma":0.000002538569,"domain_scores_codex":[0.9991383,0.00004625001,0.0002509765,0.0002310964,0.0001578049,0.0001755488],"domain_scores_gemma":[0.9993738,0.00002703334,0.0002331466,0.0001769802,0.00007869782,0.0001103226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001025069,0.0000456041,0.01967249,0.0003143761,0.00004182304,8.802385e-7,0.0001877397,1.060502e-7,0.9785478,0.000006013673,0.0000177555,0.001062928],"study_design_scores_gemma":[0.000411411,0.00005248315,0.1535754,0.00008295271,0.00004784117,0.0000566521,0.0001930501,0.00001477708,0.8454344,0.000008682958,0.000004047017,0.0001183338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972282,0.001343911,0.001126571,0.00005332822,0.00004625159,0.0001196461,0.00004417472,0.000007364683,0.00003056412],"genre_scores_gemma":[0.999311,0.0002390746,0.0001849816,0.00001455535,0.0001329299,0.000005254842,0.00008997414,0.00001246851,0.000009718021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1339029,"threshold_uncertainty_score":0.6065623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269093800430184,"score_gpt":0.2395261731588517,"score_spread":0.2268352351545498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}