{"id":"W2079961239","doi":"10.1038/cddis.2012.137","title":"CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model","year":2012,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut Gustave-Roussy; Institute of Cancer Research; Institut National Du Cancer; Fondation de France; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"CXCR4; Myeloid leukemia; Leukemia; Chemokine; Chemokine receptor; Cancer research; CXC chemokine receptors; Haematopoiesis; Bone marrow; Biology; In vivo; Jurkat cells; Immunology; Cell biology; T cell; Stem cell; Inflammation; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003596502,0.0008165268,0.0006211346,0.0007333551,0.0002543605,0.0003863252,0.0004560413,0.0005584983,0.002164809],"category_scores_gemma":[0.0001067429,0.0003469473,0.0004876426,0.0001940806,0.0003933444,0.0003166654,0.000244779,0.001284495,0.0007164666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003907301,"about_ca_system_score_gemma":0.0003587082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007398289,"about_ca_topic_score_gemma":0.001309298,"domain_scores_codex":[0.9996632,0.00006437649,0.00003092992,0.0000608891,0.00008050947,0.000099991],"domain_scores_gemma":[0.9998426,0.00002146839,0.00004838861,0.00002406607,0.00001084064,0.00005258188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005090584,0.000337941,0.0001652618,0.00005420801,0.00001367287,0.0001111293,0.00002007926,0.0001258289,0.9960173,0.0004795892,0.0001542088,0.002011748],"study_design_scores_gemma":[0.0001835241,0.002200029,0.001127315,0.00001251237,0.00004468107,0.0005440087,0.00002215509,0.00170259,0.9900846,0.0001514743,0.00391914,0.000007940298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880258,0.001997458,0.005168094,0.0003219171,0.0001001558,0.0002280565,0.0007680986,0.0004054356,0.002984938],"genre_scores_gemma":[0.9811338,0.001937193,0.005465875,0.0001410268,0.0000389257,0.0002753369,0.001124887,0.0000791607,0.009803737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164809,"threshold_uncertainty_score":0.007242024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152665050460506,"score_gpt":0.2555407786304294,"score_spread":0.2402742735843788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}