{"id":"W2079961239","doi":"10.1038/cddis.2012.137","title":"CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model","year":2012,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut Gustave-Roussy; Institute of Cancer Research; Institut National Du Cancer; Fondation de France; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"CXCR4; Myeloid leukemia; Leukemia; Chemokine; Chemokine receptor; Cancer research; CXC chemokine receptors; Haematopoiesis; Bone marrow; Biology; In vivo; Jurkat cells; Immunology; Cell biology; T cell; Stem cell; Inflammation; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001564133,0.0002755954,0.0003307918,0.0001576769,0.0001581342,0.00004430169,0.00006758288,0.0001120575,0.00004233609],"category_scores_gemma":[0.00002901571,0.0002479056,0.0001182007,0.0001348507,0.00005403057,0.0002312311,0.00007571012,0.0002672964,0.00001522031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049235,"about_ca_system_score_gemma":0.0002240424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004593847,"about_ca_topic_score_gemma":0.000001316483,"domain_scores_codex":[0.9985198,0.00003196411,0.0002900642,0.0003563674,0.0002305129,0.0005712843],"domain_scores_gemma":[0.9984439,0.00003011316,0.00008125434,0.0002166356,0.00005353914,0.001174537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003994462,0.0004551911,0.068477,0.0003288201,0.00002900886,0.00005509554,0.001216527,0.0003156467,0.9260105,0.00005171278,0.001839802,0.0008212151],"study_design_scores_gemma":[0.005120865,0.0001361825,0.01396564,0.000321214,0.0006306381,0.000009129542,0.0002749704,0.03231227,0.9452903,0.0003133948,0.0008332432,0.0007921648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957636,0.001335562,0.0003336578,0.00004890144,0.00007405223,0.0002904336,0.00003204667,0.0000639397,0.002057779],"genre_scores_gemma":[0.9958313,0.0001541081,0.0005849764,0.0003259437,0.0003124181,0.0000230637,0.00005933175,0.00004932973,0.00265954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05451136,"threshold_uncertainty_score":0.9999973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152665050460506,"score_gpt":0.2555407786304294,"score_spread":0.2402742735843788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}