{"id":"W2080020172","doi":"10.1158/1535-7163.targ-09-b236","title":"Abstract B236: A small molecule disrupts the BCL6 transcriptional repressor complex and kills lymphoma cells <i>in vitro</i> and <i>in vivo</i>","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"BCL6; Corepressor; Repressor; Chemistry; Small molecule; Cancer research; Psychological repression; Lymphoma; Biology; Cell biology; Germinal center; Stereochemistry; Biochemistry; Transcription factor; Genetics; B cell; Gene; Immunology; Antibody; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002149601,0.0002764489,0.0002294788,0.00005098488,0.00008116418,0.00006345499,0.0002173334,0.0001747425,0.00001899586],"category_scores_gemma":[0.000005379398,0.0002368586,0.00008618589,0.0001239831,0.0001463643,0.000006528949,0.00004734373,0.0001442054,0.00000103669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002743212,"about_ca_system_score_gemma":0.00006816875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007812415,"about_ca_topic_score_gemma":0.00009697928,"domain_scores_codex":[0.9985276,0.0001074708,0.0002894661,0.0005099411,0.0001684605,0.0003970572],"domain_scores_gemma":[0.9994225,0.00001941979,0.00007988702,0.0003528613,0.0000375115,0.00008785334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003256038,0.0001172182,0.000151114,0.00002222523,0.0000376221,0.00003184436,0.0001993892,0.00007912315,0.9853152,0.00008583243,0.000035495,0.01359933],"study_design_scores_gemma":[0.001595178,0.000108403,0.008674565,0.00003527831,0.00002952579,0.00002334954,0.00004547523,0.000258395,0.9698086,0.0003015719,0.01880478,0.000314892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848687,0.0114543,0.0003867669,0.001484818,0.00006649503,0.0004868189,0.0001298764,0.00001349573,0.001108703],"genre_scores_gemma":[0.9893522,0.002137993,0.0003921801,0.007849189,0.00006405922,0.00006523808,0.00003046619,0.00003198142,0.00007674898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01876928,"threshold_uncertainty_score":0.9658815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02225541570731924,"score_gpt":0.2588261525462388,"score_spread":0.2365707368389195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}