{"id":"W2080020172","doi":"10.1158/1535-7163.targ-09-b236","title":"Abstract B236: A small molecule disrupts the BCL6 transcriptional repressor complex and kills lymphoma cells <i>in vitro</i> and <i>in vivo</i>","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"BCL6; Corepressor; Repressor; Chemistry; Small molecule; Cancer research; Psychological repression; Lymphoma; Biology; Cell biology; Germinal center; Stereochemistry; Biochemistry; Transcription factor; Genetics; B cell; Gene; Immunology; Antibody; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007574091,0.0004928441,0.0003893763,0.000279368,0.0002095709,0.0002940668,0.0003410913,0.0002576993,0.004490951],"category_scores_gemma":[0.00009020913,0.0001180909,0.0002765492,0.000252173,0.000173255,0.0000976272,0.0001404723,0.0005519247,0.0007623705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002937756,"about_ca_system_score_gemma":0.0002358989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001783968,"about_ca_topic_score_gemma":0.002683703,"domain_scores_codex":[0.9999355,0.000009102045,0.000003945835,0.00001090538,0.00002190032,0.00001865009],"domain_scores_gemma":[0.999957,0.000006207295,0.00000652346,0.000003208653,0.000004904622,0.0000222031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007769071,0.0003099625,0.0002278895,0.0001483127,0.00004831528,0.0001512753,0.00001124916,0.001138231,0.9900558,0.0001433723,0.0005895146,0.006399239],"study_design_scores_gemma":[0.0005158649,0.00469237,0.002243419,0.00001396237,0.00006947595,0.0004183919,0.00002028705,0.002519164,0.9826382,0.00007327025,0.006773287,0.00002233754],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861977,0.005434773,0.001926755,0.0002074938,0.00008807163,0.0001491381,0.001589049,0.0003598386,0.004047235],"genre_scores_gemma":[0.9885521,0.002592236,0.002286937,0.0001174762,0.0000156767,0.00007394759,0.002122956,0.00004758528,0.004191197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004490951,"threshold_uncertainty_score":0.01502371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02225541570731924,"score_gpt":0.2588261525462388,"score_spread":0.2365707368389195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}