{"id":"W2080025627","doi":"10.1021/bi0521801","title":"Structure of Calmodulin Bound to a Calcineurin Peptide:  A New Way of Making an Old Binding Mode<sup>,</sup>","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Brookhaven National Laboratory; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Calmodulin; Calcineurin; Peptide; Phosphatase; Myosin light-chain kinase; Binding site; Chemistry; Serine; Biochemistry; Threonine; Protein subunit; Plasma protein binding; Myosin-light-chain phosphatase; Cell biology; Biology; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005400764,0.0002156848,0.0002489437,0.00008381889,0.0004358217,0.0004588845,0.0006519712,0.0003627209,0.001256012],"category_scores_gemma":[0.0001507006,0.0001755274,0.0001161176,0.0001351298,0.0005169422,0.0005134602,0.0001966923,0.0008647953,0.0003104743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004910759,"about_ca_system_score_gemma":0.0002145534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102687,"about_ca_topic_score_gemma":0.0010684,"domain_scores_codex":[0.9999651,0.000004470292,0.000001318948,0.000007296163,0.00001626766,0.000005605291],"domain_scores_gemma":[0.9999633,0.000005047662,0.000008891443,0.000003382631,0.000006875638,0.00001239442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005995032,0.0002016982,0.002379801,0.0004640999,0.00007254463,0.002552312,0.0003610967,0.007431337,0.9227588,0.02584727,0.01454852,0.02278301],"study_design_scores_gemma":[0.0005262115,0.001189834,0.0163643,0.0001542983,0.0001845329,0.005181101,0.0007357004,0.2012441,0.5581009,0.02012306,0.196035,0.0001608187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9346116,0.01552595,0.02462815,0.006405111,0.00106358,0.00005676506,0.0003787745,0.0005158292,0.01681422],"genre_scores_gemma":[0.9708689,0.004914784,0.01683875,0.001104928,0.0002041553,0.00002707249,0.001173875,0.00006564654,0.004801902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256012,"threshold_uncertainty_score":0.004201829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401189444277023,"score_gpt":0.2842381402259727,"score_spread":0.2702262457832025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}