{"id":"W2080025627","doi":"10.1021/bi0521801","title":"Structure of Calmodulin Bound to a Calcineurin Peptide:  A New Way of Making an Old Binding Mode<sup>,</sup>","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Brookhaven National Laboratory; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Calmodulin; Calcineurin; Peptide; Phosphatase; Myosin light-chain kinase; Binding site; Chemistry; Serine; Biochemistry; Threonine; Protein subunit; Plasma protein binding; Myosin-light-chain phosphatase; Cell biology; Biology; Phosphorylation; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008674577,0.0002735737,0.000273251,0.00005138235,0.00004662353,0.00001945622,0.0004713114,0.0002871426,0.00009700816],"category_scores_gemma":[0.0002163449,0.0002890655,0.0001461738,0.0001689148,0.00008563286,0.00000646832,0.0001899489,0.0001305,0.000003785583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004291469,"about_ca_system_score_gemma":0.0002245995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004215332,"about_ca_topic_score_gemma":0.00000916437,"domain_scores_codex":[0.9983853,0.00002983182,0.0004179982,0.0005710878,0.000259805,0.0003360302],"domain_scores_gemma":[0.9986024,0.00001250986,0.0001747072,0.0008135239,0.0001138698,0.000282932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001662349,0.00009493144,0.001243474,0.0001347951,0.00005020484,0.000004388257,0.0001906677,0.006085551,0.9892154,0.000009532333,0.001903882,0.0009009924],"study_design_scores_gemma":[0.0005562335,0.0001250859,0.000136245,0.0001052915,0.0000380379,0.0000207553,0.0001058297,0.0007709326,0.9971449,0.0000289272,0.0006748192,0.0002929846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985583,0.0003385266,0.0003041282,0.00006942347,0.00003968076,0.0001593077,0.0003327799,0.00002079146,0.0001770627],"genre_scores_gemma":[0.9935976,0.000003960057,0.004462154,0.0001647175,0.0006667069,0.000005482855,0.0002012888,0.00004843624,0.0008496153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007929511,"threshold_uncertainty_score":0.9999561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01401189444277023,"score_gpt":0.2842381402259727,"score_spread":0.2702262457832025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}