{"id":"W2080037001","doi":"10.1111/jnc.12329","title":"<scp>TMEM</scp>106B p.T185S regulates <scp>TMEM</scp>106B protein levels: implications for frontotemporal dementia","year":2013,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of British Columbia","funders":"Pacific Alzheimer Research Foundation; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research; Fondazione Cariplo; Foundation for the National Institutes of Health; Mayo Foundation for Medical Education and Research; Ministero della Salute; Mayo Clinic","keywords":"Frontotemporal lobar degeneration; Biology; Frontotemporal dementia; Cancer research; Dementia; Genetics; Pathology; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000522597,0.0004940542,0.0008307364,0.0001925723,0.0002963653,0.000242916,0.0008145447,0.0003733874,0.0002106986],"category_scores_gemma":[0.001935834,0.0004097482,0.0005640709,0.000373459,0.0002385575,0.0005388917,0.0002257421,0.001073512,0.0000798441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656471,"about_ca_system_score_gemma":0.0005648274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003453277,"about_ca_topic_score_gemma":0.000002321358,"domain_scores_codex":[0.9959843,0.00009758131,0.001366211,0.0005969763,0.0009363852,0.001018544],"domain_scores_gemma":[0.9952304,0.0005110539,0.001003907,0.000831563,0.001495274,0.0009277796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002871703,0.0003642118,0.008044695,0.0003350148,0.0003452757,0.00003886962,0.0001301704,0.0000112525,0.8994348,0.00002172248,0.08958352,0.001661743],"study_design_scores_gemma":[0.004606854,0.0009722432,0.7303312,0.0006003891,0.0003980675,0.0008987482,0.0003089306,0.0003205237,0.2134276,0.002471192,0.04548984,0.0001744433],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895879,0.001264676,0.0005803847,0.004906074,0.0001682898,0.001411679,0.00006179879,0.00007673888,0.001942461],"genre_scores_gemma":[0.9802731,0.0001055183,0.006023162,0.0005107865,0.001262008,0.000230449,0.00004450197,0.000127419,0.01142302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7222865,"threshold_uncertainty_score":0.9998354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04566210502340141,"score_gpt":0.303661450374269,"score_spread":0.2579993453508676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}