{"id":"W2080043180","doi":"10.1002/gcc.20135","title":"β‐Catenin (<i>CTNNB1</i>) gene amplification: A new mechanism of protein overexpression in cancer","year":2004,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Cyclin D1; Carcinogenesis; Molecular biology; Chromosomal translocation; Cancer; Biology; Catenin; Cancer research; Gene silencing; Cancer cell; Gene; Genetics; Wnt signaling pathway; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007434485,0.000188662,0.0002018548,0.00005056411,0.00005269875,0.00001681049,0.0001628751,0.0001517384,0.0001501158],"category_scores_gemma":[0.000005184265,0.0001703817,0.00005250074,0.0001476288,0.00005750733,0.000009467573,0.00009305491,0.00006465855,0.000001828659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005585311,"about_ca_system_score_gemma":0.0004415257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008834385,"about_ca_topic_score_gemma":0.000165286,"domain_scores_codex":[0.9989032,0.00001808889,0.000267393,0.0004028016,0.0001628517,0.0002457125],"domain_scores_gemma":[0.9995227,0.000002467511,0.0001311292,0.000188262,0.00006479104,0.00009066479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007914971,0.00003492228,0.001064821,0.00006227038,0.00003546231,0.000001313754,0.0001603031,0.000457878,0.9860379,0.0003316305,0.0002090749,0.01152528],"study_design_scores_gemma":[0.001222379,0.00008330782,0.001370769,0.0003592863,0.00001082001,0.000003918432,0.00004015629,0.000007294997,0.9879786,0.001259564,0.007423061,0.0002408735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678144,0.03049775,0.0007578499,0.000394552,0.0001041747,0.0003116728,0.00003288098,0.00001097817,0.00007577762],"genre_scores_gemma":[0.9847616,0.01138746,0.001551712,0.0001759422,0.0003634612,0.0002998592,0.0000437121,0.00002944949,0.001386816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0191103,"threshold_uncertainty_score":0.6947966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546591833733114,"score_gpt":0.2604572055581318,"score_spread":0.2449912872208007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}