{"id":"W2080059382","doi":"10.1021/tx3004938","title":"Nevirapine Bioactivation and Covalent Binding in the Skin","year":2013,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Toronto","funders":"Canadian Institutes of Health Research; Boehringer Ingelheim","keywords":"Covalent bond; Chemistry; Sulfotransferase; Covalent binding; Biochemistry; Human skin; Metabolite; Enzyme; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001382144,0.0000842421,0.0001923346,0.0003576819,0.00005253937,0.00002796711,0.0001734631,0.0001450499,0.0003758211],"category_scores_gemma":[0.0007416732,0.0000528627,0.00002792824,0.0006565532,0.0004952499,0.00006633746,0.0001674742,0.0009787151,0.0001212636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001294755,"about_ca_system_score_gemma":0.00008501498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000448761,"about_ca_topic_score_gemma":0.00002717031,"domain_scores_codex":[0.9982044,0.0002775445,0.0002197186,0.0002569556,0.0004743149,0.0005670482],"domain_scores_gemma":[0.9983276,0.001275718,0.0000165089,0.0001604886,0.00008695487,0.000132805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003308799,0.0004509806,0.04066897,0.0001701523,0.0000138439,0.0001246451,0.0004420796,3.18324e-7,0.9092417,0.002818029,0.003964487,0.04177396],"study_design_scores_gemma":[0.004655569,0.001620576,0.6114843,0.0003677484,0.000007686097,0.0003805227,0.002074587,0.002262682,0.3268394,0.0106182,0.03935483,0.0003339448],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539371,0.0003027934,0.000001341874,0.04099595,0.0000178044,0.0006394686,0.000001557914,0.00000545932,0.004098529],"genre_scores_gemma":[0.9981093,0.0004334158,0.0001445339,0.0005100215,0.0001154299,0.0002003077,0.00001502447,0.000007497677,0.0004644236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5824023,"threshold_uncertainty_score":0.4252084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1405664254385433,"score_gpt":0.4364605871046782,"score_spread":0.2958941616661349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}