{"id":"W2080059382","doi":"10.1021/tx3004938","title":"Nevirapine Bioactivation and Covalent Binding in the Skin","year":2013,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; University of Toronto","funders":"Canadian Institutes of Health Research; Boehringer Ingelheim","keywords":"Covalent bond; Chemistry; Sulfotransferase; Covalent binding; Biochemistry; Human skin; Metabolite; Enzyme; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221068,0.0004083544,0.0001511736,0.0002671375,0.0002045884,0.0002371814,0.0001735278,0.0003270731,0.001619042],"category_scores_gemma":[0.0001260255,0.0002148048,0.0003107444,0.000138549,0.000144149,0.0001844594,0.000202173,0.0004774625,0.0003340432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206364,"about_ca_system_score_gemma":0.0001365052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009011543,"about_ca_topic_score_gemma":0.001545505,"domain_scores_codex":[0.9997798,0.00004271604,0.00000988037,0.00004402574,0.00008396953,0.00003960264],"domain_scores_gemma":[0.9999218,0.00001006649,0.00002634888,0.00001245223,0.00001375465,0.00001561787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002326653,0.00001057557,0.0002060454,0.00001882053,0.000007925805,0.00004460875,0.000008346663,0.00001078589,0.9988673,0.00003379638,0.00001013347,0.0007584225],"study_design_scores_gemma":[0.000008510345,0.0002612245,0.03823447,0.00001097243,0.00002325406,0.001041105,0.00004858813,0.0007990304,0.9569986,0.00008354981,0.002484496,0.000006036442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850272,0.004304689,0.005195928,0.00008689732,0.0000300408,0.00005833321,0.0002093849,0.0001005335,0.004986975],"genre_scores_gemma":[0.9899504,0.00164499,0.00314127,0.00007255869,0.00001322172,0.00003566697,0.0004635425,0.00001478272,0.004663555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619042,"threshold_uncertainty_score":0.005416214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1405664254385433,"score_gpt":0.4364605871046782,"score_spread":0.2958941616661349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}