{"id":"W2080071903","doi":"10.1097/01.cad.0000203388.68034.06","title":"Inhibition of MMP-9 secretion by the anti-metastatic PSP94-derived peptide PCK3145 requires cell surface laminin receptor signaling","year":2006,"lang":"en","type":"article","venue":"Anti-Cancer Drugs","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal","funders":"","keywords":"Laminin; MAPK/ERK pathway; Protein kinase A; Biology; Molecular biology; Cell growth; Cell adhesion; Cell biology; Cell surface receptor; Kinase; Extracellular; Extracellular matrix; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236817,0.0004213811,0.0003475793,0.0001536169,0.00016574,0.000274557,0.0001921328,0.0002575841,0.00151854],"category_scores_gemma":[0.0001096934,0.0001693957,0.0003144092,0.0002477692,0.0002114988,0.0001481396,0.0001824151,0.0007539751,0.0004849073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003422504,"about_ca_system_score_gemma":0.0003345869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004798977,"about_ca_topic_score_gemma":0.0006856354,"domain_scores_codex":[0.9997639,0.00002874359,0.00002423548,0.00003561937,0.0000748385,0.00007272381],"domain_scores_gemma":[0.9999059,0.00002021683,0.00002365344,0.00001186328,0.00001010678,0.000028211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008551961,0.00005491753,0.00006160458,0.00002555386,0.000002773445,0.00003076933,0.000005805808,0.00004783213,0.9989766,0.00003805816,0.00002876492,0.0006417814],"study_design_scores_gemma":[0.0000221935,0.0003454188,0.002030856,0.000002659037,0.000005954724,0.0001035992,0.000008142054,0.0006283082,0.9960897,0.00001548767,0.0007457128,0.000001968169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99496,0.001006176,0.001938757,0.00008476048,0.0000320584,0.00005486019,0.0004369452,0.00007398977,0.001412526],"genre_scores_gemma":[0.9921651,0.0009516389,0.002620132,0.00004940591,0.00001139633,0.00007358321,0.001287935,0.00001547492,0.00282535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151854,"threshold_uncertainty_score":0.005080044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008405670631498089,"score_gpt":0.2313227782179116,"score_spread":0.2229171075864135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}