{"id":"W2080093229","doi":"10.1002/tox.20087","title":"Life-cycle exposure of fathead minnows (Pimephales promelas) to an ethinylestradiol concentration below 1 ng/L reduces egg fertilization success and demasculinizes males","year":2005,"lang":"en","type":"article","venue":"Environmental Toxicology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":343,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"","keywords":"Gonadosomatic Index; Pimephales promelas; Minnow; Human fertilization; Biology; Fecundity; Juvenile; Reproduction; Animal science; Secondary sex characteristic; Endocrinology; Fish <Actinopterygii>; Population; Ecology; Fishery; Anatomy; Hormone; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002018921,0.0001691523,0.0002074628,0.00003439973,0.00008722992,0.00001193633,0.0001384596,0.0002429516,0.0001226474],"category_scores_gemma":[0.0002048986,0.0001554608,0.00003714366,0.00004171158,0.0003911685,0.00002793824,0.00006323437,0.00007209757,0.000009522786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002452697,"about_ca_system_score_gemma":0.00004113785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002922729,"about_ca_topic_score_gemma":0.00003269599,"domain_scores_codex":[0.9987681,0.0001833956,0.000293516,0.000453837,0.0000933795,0.000207784],"domain_scores_gemma":[0.9994332,0.00002379279,0.0001250589,0.0002425476,0.00001265919,0.0001627672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002010678,0.0002584257,0.0541213,0.000008735876,0.0000433877,7.098495e-7,0.0004967873,0.0002640801,0.9367419,0.0000628697,0.00009151439,0.00770923],"study_design_scores_gemma":[0.0004399456,0.001399973,0.3290462,0.000006180882,0.00002040965,0.00001815885,0.0005047155,0.00006517278,0.6663355,0.0000297613,0.0019718,0.0001621136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966761,0.001325926,0.000223085,0.001073756,0.00008848999,0.0003951927,0.0000313813,0.000009753874,0.0001763469],"genre_scores_gemma":[0.9969727,0.00040445,0.001527687,0.0004137229,0.0002530842,0.00003312856,0.0001533655,0.00001558047,0.0002262604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2749249,"threshold_uncertainty_score":0.6339507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01290700758300695,"score_gpt":0.2619208137363957,"score_spread":0.2490138061533888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}