{"id":"W2080125220","doi":"10.1158/0008-5472.sabcs12-p3-12-04","title":"Abstract P3-12-04: A phase 2, multi-center, open label study evaluating the efficacy and safety of GRN1005 alone or in combination with trastuzumab in patients with brain metastases from breast cancer","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Brain metastasis; Trastuzumab; Breast cancer; Internal medicine; Clinical endpoint; Oncology; Metastatic breast cancer; Phases of clinical research; Concomitant; Cancer; Toxicity; Metastasis; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001719384,0.001933999,0.00217686,0.0005951325,0.0005097553,0.001038732,0.001368146,0.001567385,0.005264911],"category_scores_gemma":[0.0006820026,0.0007017878,0.001005587,0.0005297778,0.001445014,0.001070948,0.0004345247,0.004651762,0.001649781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009783966,"about_ca_system_score_gemma":0.002007378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069822,"about_ca_topic_score_gemma":0.002252428,"domain_scores_codex":[0.999461,0.0002557727,0.00002333123,0.0001019956,0.00005585525,0.0001020535],"domain_scores_gemma":[0.9992934,0.00009406284,0.0001046397,0.00006061644,0.0000480392,0.0003992156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6739688,0.1726105,0.005347196,0.0008387368,0.0009272228,0.0003593687,0.0002924524,0.001784198,0.0831266,0.0001860426,0.003338285,0.05722049],"study_design_scores_gemma":[0.4342796,0.5501077,0.007055684,0.00001788284,0.0002794316,0.0002144249,0.00004289827,0.0006807361,0.005705439,0.0001057456,0.001487536,0.00002289916],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921467,0.0009738799,0.0005286467,0.0003403187,0.00006959292,0.003314863,0.001254303,0.000135977,0.001235878],"genre_scores_gemma":[0.9862996,0.0009444282,0.00184462,0.0007549037,0.0001609637,0.003973801,0.002635288,0.00004924116,0.003337174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005264911,"threshold_uncertainty_score":0.01761287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2023108857503206,"score_gpt":0.4949433606732567,"score_spread":0.2926324749229361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}