{"id":"W2080126527","doi":"10.1158/1538-7445.prca2012-b19","title":"Abstract B19: Induction of apoptosis and antitumor activity of the AKT inhibitor AZD5363 is enhanced by combination with hormonal therapies in preclinical models of prostate cancer","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada); University of British Columbia","funders":"","keywords":"LNCaP; PTEN; Prostate cancer; Cancer research; Protein kinase B; Bicalutamide; Growth inhibition; Androgen receptor; In vivo; Enzalutamide; Medicine; Cancer; Cell growth; PI3K/AKT/mTOR pathway; Apoptosis; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028589,0.0004800242,0.0006933338,0.0006640934,0.0002228783,0.0003379528,0.0003726558,0.0003245785,0.00303162],"category_scores_gemma":[0.0001166364,0.0001881686,0.000345199,0.0004652397,0.0002367815,0.0001919648,0.0001810505,0.001049138,0.0005374042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003565489,"about_ca_system_score_gemma":0.0003841229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290836,"about_ca_topic_score_gemma":0.002016918,"domain_scores_codex":[0.9998023,0.00003334617,0.00002103765,0.0000290797,0.00006068358,0.00005351269],"domain_scores_gemma":[0.9999005,0.00001269152,0.00002369243,0.00001341522,0.00001167395,0.00003806437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003217184,0.001269417,0.000398983,0.0001514784,0.00004780711,0.00009425074,0.0000376471,0.000662302,0.9813932,0.0001683526,0.0005064708,0.01205299],"study_design_scores_gemma":[0.0005227698,0.01589591,0.005441389,0.00001883908,0.00007966306,0.0002547312,0.00002839442,0.001439989,0.972567,0.00006711642,0.003671358,0.00001291726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917303,0.002613465,0.001117267,0.0001786379,0.00009746577,0.0001238097,0.001139282,0.0003176694,0.002682285],"genre_scores_gemma":[0.9942209,0.001363816,0.000869401,0.0000453271,0.00001816962,0.00008378328,0.001145834,0.00002560632,0.002227356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00303162,"threshold_uncertainty_score":0.01014173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1030909955851011,"score_gpt":0.4244559278064584,"score_spread":0.3213649322213573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}