{"id":"W2080127092","doi":"10.1016/j.bbapap.2009.12.001","title":"Dissecting the role of mTOR: Lessons from mTOR inhibitors","year":2009,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":453,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"PI3K/AKT/mTOR pathway; mTORC1; mTORC2; Sirolimus; Mechanistic target of rapamycin; RPTOR; Kinase; Cell growth; Biology; Cancer research; Allosteric regulation; Signal transduction; Cell biology; Pharmacology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004202624,0.0009094473,0.001402128,0.0001071068,0.0002735742,0.0001556939,0.0009569787,0.0008812366,0.000009823491],"category_scores_gemma":[0.0001660998,0.0006624237,0.0007410057,0.0002978191,0.0003544606,0.00001654563,0.000491538,0.0007787441,0.000006127391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006918189,"about_ca_system_score_gemma":0.0005362457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001829658,"about_ca_topic_score_gemma":0.00002489282,"domain_scores_codex":[0.9966435,0.0003230442,0.0009438678,0.001174766,0.0003566884,0.000558102],"domain_scores_gemma":[0.9970831,0.0000983842,0.001227257,0.00125133,0.0001643485,0.0001755658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114042,0.0001884283,0.000001377053,0.001270424,0.0005708123,0.000001723273,0.0001632618,0.000001236154,0.8468673,0.0001771715,0.0002225149,0.1504244],"study_design_scores_gemma":[0.0002883415,0.0005064225,0.00001273102,0.00295087,0.0005137845,0.00001010708,0.00005079397,0.00001207131,0.7009346,0.0006081264,0.2932752,0.0008369272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1833941,0.8111666,0.00004536217,0.0002932569,0.0003322886,0.003360409,0.001083318,0.00004862814,0.0002759778],"genre_scores_gemma":[0.06982177,0.9236012,0.002192738,0.0001061597,0.002483285,0.000679534,0.0007729686,0.000201084,0.0001412697],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2930527,"threshold_uncertainty_score":0.9995827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137623598597172,"score_gpt":0.303262044732183,"score_spread":0.2818858087462113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}