{"id":"W2080127092","doi":"10.1016/j.bbapap.2009.12.001","title":"Dissecting the role of mTOR: Lessons from mTOR inhibitors","year":2009,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":453,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"PI3K/AKT/mTOR pathway; mTORC1; mTORC2; Sirolimus; Mechanistic target of rapamycin; RPTOR; Kinase; Cell growth; Biology; Cancer research; Allosteric regulation; Signal transduction; Cell biology; Pharmacology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001315652,0.001278135,0.001846646,0.001922381,0.0003960551,0.001700104,0.001476977,0.002112245,0.00173175],"category_scores_gemma":[0.001184528,0.0005120321,0.0005732215,0.00226974,0.001729941,0.003538523,0.001237464,0.004269621,0.001895143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001407953,"about_ca_system_score_gemma":0.001137545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001542317,"about_ca_topic_score_gemma":0.002770992,"domain_scores_codex":[0.9997742,0.00002815802,0.00002786569,0.00005393366,0.00008721431,0.0000286098],"domain_scores_gemma":[0.9994716,0.0002667512,0.00003956778,0.00002083736,0.0001426974,0.00005855022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002269423,0.0001271017,0.0001828614,0.007698204,0.0001280037,0.0003459187,0.00007492562,0.0006122975,0.004241618,0.01172219,0.06523225,0.9094076],"study_design_scores_gemma":[0.00005115626,0.00007401217,0.0004529689,0.00125877,0.00007779767,0.0008286955,0.00006000191,0.000158481,0.001741447,0.006535701,0.9887344,0.00002664362],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009301927,0.9982378,0.0002093595,0.0006146196,0.0002435491,0.000001668689,0.0000103236,0.000005695263,0.0005838842],"genre_scores_gemma":[0.0006140515,0.9977803,0.0002675469,0.0005537783,0.0003037063,0.00000381826,0.00001787151,0.000002396416,0.0004566341],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002112245,"threshold_uncertainty_score":0.01021546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137623598597172,"score_gpt":0.303262044732183,"score_spread":0.2818858087462113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}