{"id":"W2080136671","doi":"10.1016/j.molbiopara.2012.05.005","title":"Single nucleotide polymorphisms in β-tubulin selected in Onchocerca volvulus following repeated ivermectin treatment: Possible indication of resistance selection","year":2012,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Onchocerca volvulus; Ivermectin; Onchocerciasis; Biology; Single-nucleotide polymorphism; Genotype; Population; Genetics; Immunology; Gene; Zoology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009033939,0.0001565738,0.000353524,0.0002566317,0.00002782882,0.000005905458,0.00004061315,0.000156526,0.00001617811],"category_scores_gemma":[0.0001675164,0.0001413916,0.00007509808,0.0006647622,0.00008398415,0.00005095524,0.00001629404,0.0001210744,0.000005851338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046026,"about_ca_system_score_gemma":0.0001012808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002813204,"about_ca_topic_score_gemma":0.00008185994,"domain_scores_codex":[0.9987121,0.0001205259,0.0002913573,0.0002900685,0.0001560099,0.0004299212],"domain_scores_gemma":[0.9994925,0.00005520091,0.00006690146,0.0001387682,0.00004160032,0.0002050326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005785471,0.0009593923,0.4954524,0.00001590421,0.00007074755,0.00009472307,0.00009617622,5.454985e-7,0.5021084,0.00001868587,0.00001735854,0.000587147],"study_design_scores_gemma":[0.002124828,0.0003450703,0.4629954,0.00005648746,0.00007224042,0.00003539643,0.00001858988,0.00003870843,0.5341642,0.00004780591,0.00001973641,0.00008153878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954167,0.003168066,0.00003789152,0.0001984375,0.00003130555,0.0003599819,0.000005432879,0.00002336032,0.0007588004],"genre_scores_gemma":[0.9993471,0.00004458841,0.0003119645,0.00003881681,0.00002275295,0.00004057411,0.0001090197,0.00001349905,0.00007172168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03245699,"threshold_uncertainty_score":0.5765782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159540733367215,"score_gpt":0.3056078937942668,"score_spread":0.2940124864605947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}