{"id":"W2080152736","doi":"10.1016/j.cell.2008.05.024","title":"Variation in Homeodomain DNA Binding Revealed by High-Resolution Analysis of Sequence Preferences","year":2008,"lang":"en","type":"article","venue":"Cell","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":637,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute","keywords":"Homeobox; Biology; Genetics; Sequence (biology); DNA; Computational biology; Evolutionary biology; DNA binding site; Binding site; DNA sequencing; Genome; Gene; Transcription factor; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026089,0.0001988986,0.0004954602,0.0005416145,0.0002276816,0.0005173403,0.0004716206,0.0004400398,0.001310102],"category_scores_gemma":[0.0003094991,0.0003538283,0.0003331241,0.0005860964,0.0003481381,0.000184401,0.0003064446,0.0009811785,0.0005346322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576114,"about_ca_system_score_gemma":0.0001171005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001415057,"about_ca_topic_score_gemma":0.002671081,"domain_scores_codex":[0.999856,0.00002280112,0.000009958746,0.00004452669,0.00003593256,0.00003072882],"domain_scores_gemma":[0.9995554,0.0001689428,0.0001054057,0.00005308076,0.00004340079,0.00007373309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001045227,0.00001172889,0.0009657784,0.00001029014,0.00001216292,0.00002660742,0.00002510661,0.00008231214,0.9979873,0.00008870923,0.00001726467,0.0006681969],"study_design_scores_gemma":[0.00004852357,0.0002450215,0.2489754,0.00001275655,0.0001138033,0.001732205,0.0001802765,0.005739218,0.7393426,0.0005035475,0.003052397,0.00005423562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957209,0.0003645835,0.00280596,0.00002828067,0.000007027822,0.000006193685,0.0003410615,0.00002862956,0.0006974033],"genre_scores_gemma":[0.9965829,0.0001581911,0.001886058,0.000047694,0.000005506154,0.00001108909,0.0006805288,0.00003499522,0.0005930933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001415057,"threshold_uncertainty_score":0.00438273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794442105333799,"score_gpt":0.2232316429410226,"score_spread":0.2052872218876846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}