{"id":"W2080158135","doi":"10.2174/092986710791299948","title":"Regulatory Effects of Peptides from the Pro and Catalytic Domains of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) on Low-Density Lipoprotein Receptor (LDL-R)","year":2010,"lang":"en","type":"article","venue":"Current Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Kexin; PCSK9; Proprotein convertase; Subtilisin; LDL receptor; Proprotein Convertases; Chemistry; Biochemistry; Peptide; Recombinant DNA; Lipoprotein; Receptor; Low-density lipoprotein; Cholesterol; Enzyme; Internal medicine; Endocrinology; Biology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000986987,0.0001996802,0.0001122884,0.00006468294,0.00005554658,0.0001565713,0.00009329599,0.0001173933,0.001207388],"category_scores_gemma":[0.0001134496,0.00007101899,0.0001612074,0.00005088522,0.0001273924,0.00008600386,0.00008186349,0.0002550295,0.0002884035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001325102,"about_ca_system_score_gemma":0.00009253119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002423273,"about_ca_topic_score_gemma":0.0002044036,"domain_scores_codex":[0.9999455,0.00001236485,0.000005229639,0.000009915729,0.00001154165,0.00001541407],"domain_scores_gemma":[0.9999152,0.00002771526,0.00002464884,0.000004798526,0.000006806363,0.00002074429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001146595,0.00005351376,0.0002201696,0.00004845921,0.000005625235,0.00008038563,0.000009225892,0.00009990062,0.9969544,0.00004768463,0.00003039675,0.001303567],"study_design_scores_gemma":[0.00004181226,0.0006472064,0.003145272,0.000004791265,0.00001332529,0.0001817129,0.00001349021,0.0005053223,0.9946986,0.00002031447,0.0007255236,0.000002683875],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980847,0.0007624882,0.0003628065,0.00002247973,0.00001467406,0.000009141829,0.000123412,0.00001158237,0.0006087634],"genre_scores_gemma":[0.9974781,0.0006259091,0.0007004132,0.00002596187,0.000008809861,0.00001513707,0.0002520578,0.00000669453,0.0008869303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207388,"threshold_uncertainty_score":0.004039109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004920645274355449,"score_gpt":0.2204960485335363,"score_spread":0.2155754032591808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}