{"id":"W2080158135","doi":"10.2174/092986710791299948","title":"Regulatory Effects of Peptides from the Pro and Catalytic Domains of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) on Low-Density Lipoprotein Receptor (LDL-R)","year":2010,"lang":"en","type":"article","venue":"Current Medicinal Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Canadian Institutes of Health Research","keywords":"Kexin; PCSK9; Proprotein convertase; Subtilisin; LDL receptor; Proprotein Convertases; Chemistry; Biochemistry; Peptide; Recombinant DNA; Lipoprotein; Receptor; Low-density lipoprotein; Cholesterol; Enzyme; Internal medicine; Endocrinology; Biology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146637,0.000260695,0.0003116016,0.00001678606,0.00007279456,0.000008522255,0.0002819904,0.0002360207,0.00002902749],"category_scores_gemma":[0.000624023,0.0001879912,0.0001046469,0.00005841263,0.0005013614,0.000007443508,0.0001387093,0.0004254476,0.000003356747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001389132,"about_ca_system_score_gemma":0.0001643193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009911619,"about_ca_topic_score_gemma":0.00000981613,"domain_scores_codex":[0.9985474,0.00005237847,0.0003412217,0.0004564407,0.0003697535,0.0002328229],"domain_scores_gemma":[0.9986624,0.00006249865,0.0002736939,0.0007083084,0.0001297105,0.0001633801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002896287,0.0001825173,0.0002899769,0.0008204303,0.0000430135,0.000003975587,0.0001106548,1.150088e-7,0.9917499,0.00002829847,0.000837346,0.005644185],"study_design_scores_gemma":[0.001036919,0.0002693119,0.0007400531,0.0006983039,0.00006167084,0.000007456115,0.00007036431,0.00001001649,0.9956672,0.0001937891,0.001054831,0.0001900845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965347,0.002134907,0.00004727937,0.0001060449,0.0003604587,0.0006768029,0.00006275002,0.00001158514,0.00006547593],"genre_scores_gemma":[0.9985883,0.00006662952,0.00009516397,0.00005530608,0.0008377073,0.00006902867,0.0002045861,0.00002243416,0.00006079198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005454101,"threshold_uncertainty_score":0.766606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004920645274355449,"score_gpt":0.2204960485335363,"score_spread":0.2155754032591808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}