{"id":"W2080193860","doi":"10.1186/1746-6148-6-8","title":"Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole: failure of its therapeutic activity against triclabendazole-resistant liver flukes","year":2010,"lang":"en","type":"article","venue":"BMC Veterinary Research","topic":"Helminth infection and control","field":"Veterinary","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agencia Nacional de Promoción Científica y Tecnológica; Directorate for Biological Sciences; Universidad Nacional del Centro de la Provincia de Buenos Aires; Queen's University; Consejo Nacional de Investigaciones Científicas y Técnicas","keywords":"Triclabendazole; Fasciola hepatica; Ivermectin; Hepatica; Pharmacokinetics; Pharmacology; Liver fluke; Biology; Internal medicine; Medicine; Veterinary medicine; Immunology; Helminths","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463232,0.0002108145,0.0004185524,0.0000972075,0.00005601575,0.0002229637,0.0001505997,0.0002070691,0.0007394374],"category_scores_gemma":[0.0003697188,0.0001100353,0.0001195747,0.0001068966,0.0001844425,0.0001770834,0.00006233856,0.0003526083,0.0002177522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961696,"about_ca_system_score_gemma":0.0001675693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005293193,"about_ca_topic_score_gemma":0.0006142257,"domain_scores_codex":[0.9998872,0.00002871393,0.000008735216,0.0000254779,0.00002611507,0.00002377827],"domain_scores_gemma":[0.9997614,0.00004583399,0.00008688851,0.0000288124,0.00004148222,0.0000356028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002986884,0.0001125206,0.002023739,0.00007653954,0.00002265758,0.0000863959,0.0000364437,0.0001307324,0.9880509,0.00001942736,0.00006362438,0.006390146],"study_design_scores_gemma":[0.0001122835,0.008733772,0.03490287,0.0000123247,0.00006601134,0.0006268395,0.00005467498,0.002230369,0.9514595,0.00002601914,0.001763324,0.00001201067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980012,0.0008909072,0.0005898213,0.00003238836,0.00001068348,0.00001494134,0.0001196341,0.00002332334,0.0003171907],"genre_scores_gemma":[0.9982899,0.0002696938,0.0005808435,0.00001731186,0.000008697473,0.00001609243,0.000194026,0.000006786647,0.0006166518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007394374,"threshold_uncertainty_score":0.002473652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1663726217370012,"score_gpt":0.4107836501622342,"score_spread":0.244411028425233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}