{"id":"W2080231296","doi":"10.3109/07420528.2012.691145","title":"Chronomics of Pressure Overload–Induced Cardiac Hypertrophy in Mice Reveals Altered Day/Night Gene Expression and Biomarkers of Heart Disease","year":2012,"lang":"en","type":"article","venue":"Chronobiology International","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Guelph","funders":"U.S. Public Health Service","keywords":"Disease; Gene expression profiling; Gene expression; Pressure overload; Real-time polymerase chain reaction; Muscle hypertrophy; Left ventricular hypertrophy; Circadian rhythm; Microarray; Medicine; DNA microarray; Biomarker; Heart disease; Bioinformatics; Internal medicine; Gene; Biology; Blood pressure; Endocrinology; Cardiac hypertrophy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748913,0.0001227241,0.0002484608,0.0001407799,0.00002622958,0.000005186168,0.0001606088,0.00009983099,0.00008610619],"category_scores_gemma":[0.0001984044,0.0001154767,0.00006979797,0.00006287677,0.0001941971,0.0001789663,0.0001066112,0.00009346769,0.000007291856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000506071,"about_ca_system_score_gemma":0.00005845437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001994598,"about_ca_topic_score_gemma":6.432079e-7,"domain_scores_codex":[0.9989488,0.000157852,0.0003069339,0.0002799496,0.00008990832,0.0002165899],"domain_scores_gemma":[0.9993261,0.0001905469,0.0001615972,0.000175567,0.00002828073,0.0001178997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001113421,0.00007604747,0.1270187,0.00001990269,0.00001905165,0.000001004313,0.0001529722,0.00001182914,0.8714666,0.0006355666,0.0003585227,0.0001284556],"study_design_scores_gemma":[0.0005024765,0.00003000827,0.3454503,0.00003743588,0.00001323343,0.00000768957,0.00001078487,0.00008063915,0.6514283,0.00003295189,0.002315374,0.00009074059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959372,0.001798811,0.00002022367,0.0001900874,0.00124198,0.0001988707,0.0002981046,0.000008659234,0.0003061193],"genre_scores_gemma":[0.999189,0.0001073396,0.0001921535,0.0001238947,0.0002418477,0.00001845506,0.00002958441,0.00001108928,0.00008669961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2200383,"threshold_uncertainty_score":0.4709003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01973094876495574,"score_gpt":0.2594257796321317,"score_spread":0.239694830867176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}