{"id":"W2080237506","doi":"10.1126/science.1068327","title":"Effect of <i>p53</i> Status on Tumor Response to Antiangiogenic Therapy","year":2002,"lang":"en","type":"article","venue":"Science","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":429,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; McMaster University Medical Centre; Hamilton General Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"National Cancer Institute","keywords":"Genetic enhancement; Antiangiogenic therapy; Cancer research; Apoptosis; Cancer therapy; Colorectal cancer; Suppressor; Medicine; Tumor suppressor gene; Biology; Cancer; Immunology; Gene; Internal medicine; Angiogenesis; Carcinogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598746,0.000257764,0.0003973299,0.0002091495,0.0001072952,0.0003635999,0.0002002039,0.0002882566,0.001640111],"category_scores_gemma":[0.0003278471,0.0001300052,0.0001419553,0.0001545137,0.0002634322,0.0001883092,0.0001078485,0.0005994884,0.0002087738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897954,"about_ca_system_score_gemma":0.0001424233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004788559,"about_ca_topic_score_gemma":0.0004480674,"domain_scores_codex":[0.9997786,0.00007225775,0.0000213609,0.00003341418,0.0000327062,0.00006177646],"domain_scores_gemma":[0.9995148,0.0001782456,0.0001057189,0.0000405814,0.0000275296,0.000133123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002031347,0.0002350241,0.0004853369,0.00003326282,0.00001725407,0.00007483998,0.00001723269,0.0002090475,0.9939075,0.00009766057,0.000117479,0.002773975],"study_design_scores_gemma":[0.0001052074,0.004386749,0.006687485,0.000008557616,0.00005991659,0.0002863159,0.00002817717,0.001191877,0.9854311,0.00005930959,0.001745229,0.0000101544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970703,0.0008090048,0.0003692308,0.0001190749,0.00003821112,0.00001812467,0.0002224129,0.00005197208,0.001301687],"genre_scores_gemma":[0.9983084,0.0003925664,0.000247957,0.00006051968,0.00001279653,0.00001433688,0.0002204465,0.00002166461,0.0007211979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001640111,"threshold_uncertainty_score":0.005486727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008057011921442772,"score_gpt":0.2659152886500309,"score_spread":0.2578582767285881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}