{"id":"W2080284495","doi":"10.3389/fonc.2013.00288","title":"A Predictive Genetic Signature for Response to Fluoropyrimidine-Based Neoadjuvant Chemoradiation in Clinical Stage II and III Rectal Cancer","year":2013,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Colorectal Cancer Surgical Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; National Institutes of Health; Jacobs Foundation; Cancer Research UK","keywords":"Neoadjuvant therapy; Colorectal cancer; Medicine; Pathological; Complete response; Oncology; Stage (stratigraphy); Gene signature; Cancer; Internal medicine; Gene expression profiling; Gene expression; Chemotherapy; Gene; Breast cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001014956,0.0001728545,0.0001770604,0.000454886,0.0001866152,0.0001982893,0.00008618349,0.0002208025,0.0009752709],"category_scores_gemma":[0.0005435972,0.00007241361,0.0001839831,0.0003680215,0.00018236,0.0000914462,0.0001006369,0.0001783704,0.0001287968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453482,"about_ca_system_score_gemma":0.0002306325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009810714,"about_ca_topic_score_gemma":0.001753571,"domain_scores_codex":[0.9998995,0.00002136479,0.00000873509,0.00002385497,0.00002564816,0.00002095679],"domain_scores_gemma":[0.9996979,0.00008812984,0.0001269456,0.00001312656,0.00002739796,0.00004657671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009031274,0.00007342903,0.9356763,0.00004191396,0.00005181229,0.000255592,0.00005309615,0.0008130682,0.05226633,0.00003724426,0.0001673914,0.009660777],"study_design_scores_gemma":[0.00001005427,0.0002105312,0.9916625,0.000005300683,0.00003937258,0.0007850843,0.00006944395,0.002161806,0.004750805,0.00007676811,0.0002234811,0.000004903523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999156,0.000104992,0.0003443524,0.0000282343,0.000001843859,0.000007566232,0.0002008088,0.000005185769,0.0001509859],"genre_scores_gemma":[0.999188,0.00003577439,0.0003780834,0.0000112363,0.000002442261,0.000008082796,0.0002899828,0.000001311779,0.00008491796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009810714,"threshold_uncertainty_score":0.003262639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025438423881731,"score_gpt":0.3526927380087194,"score_spread":0.3324383537699021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}