{"id":"W2080294402","doi":"10.1007/s11010-007-9535-1","title":"Plasma methylglyoxal and glyoxal are elevated and related to early membrane alteration in young, complication-free patients with Type 1 diabetes","year":2007,"lang":"en","type":"article","venue":"Molecular and Cellular Biochemistry","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":134,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. John’s Health Sciences Centre; Health Sciences Centre; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Janeway Children's Hospital Foundation","keywords":"Methylglyoxal; Glyoxal; Glycation; Chemistry; Lipid peroxidation; Internal medicine; Diabetes mellitus; Endocrinology; Biochemistry; Enzyme; Fructosamine; ATPase; Lactoylglutathione lyase; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246506,0.0001859324,0.000146226,0.00006797239,0.00007275723,0.00004017334,0.0001185223,0.0001596914,0.000004859367],"category_scores_gemma":[0.0001801566,0.0001827848,0.00001498435,0.0002361281,0.0001103092,0.000009494403,0.0001422771,0.0001398321,0.000001406991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001777607,"about_ca_system_score_gemma":0.00002448243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001140912,"about_ca_topic_score_gemma":0.00001074027,"domain_scores_codex":[0.9987073,0.00003995782,0.0002096166,0.0005478789,0.0001872607,0.0003079746],"domain_scores_gemma":[0.9991616,0.00001409344,0.00007031651,0.0003834198,0.000184496,0.000186069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001715001,0.00004544084,0.06743244,0.00004808118,0.00003186373,0.00000588514,0.00003495406,0.0000137225,0.9316104,0.00002986919,0.00001470943,0.0005611455],"study_design_scores_gemma":[0.001159001,0.0002002859,0.03247507,0.00002554351,0.00001293286,0.000006459911,0.00004381216,0.00003244483,0.9656142,0.00007337856,0.000128233,0.000228658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978955,0.0006983491,0.0007087612,0.0001531602,0.00002332744,0.0002885059,0.00001788172,0.00001175798,0.0002026994],"genre_scores_gemma":[0.9982164,0.00002126316,0.001059678,0.00006940886,0.00001965104,0.00001293823,0.0004110271,0.00002704908,0.0001625951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03495737,"threshold_uncertainty_score":0.745375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004154013463508264,"score_gpt":0.2284156077531563,"score_spread":0.224261594289648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}