{"id":"W2080302192","doi":"10.1021/bi0617759","title":"Roles of Salt and Conformation in the Biological and Physicochemical Behavior of Protegrin-1 and Designed Analogues:  Correlation of Antimicrobial, Hemolytic, and Lipid Bilayer-Perturbing Activities","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Antimicrobial; Peptide; Lipid bilayer; Amphiphile; Antimicrobial peptides; Liposome; Biological activity; Stereochemistry; Disulfide bond; Biochemistry; Biophysics; Membrane; Organic chemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195233,0.0002438819,0.0002380151,0.0001156897,0.00006418431,0.00027315,0.0001630161,0.0002484112,0.0002920553],"category_scores_gemma":[0.0004590864,0.0001185142,0.0001448504,0.0001382551,0.0002065577,0.0002825977,0.0001512349,0.0002955888,0.0001057951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135342,"about_ca_system_score_gemma":0.00008603191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243565,"about_ca_topic_score_gemma":0.0002284775,"domain_scores_codex":[0.9998338,0.00004326001,0.00002400708,0.00002871272,0.00004476888,0.00002536759],"domain_scores_gemma":[0.9997374,0.00006300648,0.00009645788,0.00001778559,0.00003988899,0.0000453777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000292887,0.00002283327,0.001078403,0.00002427689,0.000007430629,0.00004149237,0.00001776642,0.0003755711,0.9970407,0.00002305422,0.000009226848,0.00106637],"study_design_scores_gemma":[0.000007900182,0.000344355,0.004410593,0.000002932569,0.00001039225,0.0001249294,0.00001771518,0.001285868,0.9935333,0.00001859143,0.0002354768,0.000007934666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987513,0.000578653,0.0004239087,0.00001657327,0.000004348479,0.000008856646,0.00006103124,0.000009923306,0.0001453382],"genre_scores_gemma":[0.9988525,0.000200589,0.0006427655,0.00002028498,0.00000220989,0.0000072399,0.0001183955,0.000005756089,0.0001502108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0002920553,"threshold_uncertainty_score":0.001549304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009472176152424228,"score_gpt":0.2117296007424276,"score_spread":0.2022574245900034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}