{"id":"W2080302192","doi":"10.1021/bi0617759","title":"Roles of Salt and Conformation in the Biological and Physicochemical Behavior of Protegrin-1 and Designed Analogues:  Correlation of Antimicrobial, Hemolytic, and Lipid Bilayer-Perturbing Activities","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences","keywords":"Chemistry; Antimicrobial; Peptide; Lipid bilayer; Amphiphile; Antimicrobial peptides; Liposome; Biological activity; Stereochemistry; Disulfide bond; Biochemistry; Biophysics; Membrane; Organic chemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001216685,0.0001176455,0.0002584604,0.00003891242,0.0000460505,0.000007847852,0.00004688463,0.0001897043,0.000003677918],"category_scores_gemma":[0.00002726955,0.00008570631,0.00002475788,0.00004529961,0.0007693399,0.00007746304,0.00004929928,0.0001076464,8.310879e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005469481,"about_ca_system_score_gemma":0.0000170313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001005369,"about_ca_topic_score_gemma":0.000005068969,"domain_scores_codex":[0.9994274,0.00004168829,0.0002584153,0.0001426034,0.00002244203,0.0001074593],"domain_scores_gemma":[0.9995458,0.0001471911,0.0001957942,0.00007747194,0.00002650242,0.000007210835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009934021,0.00009393071,0.01514358,0.0001625759,0.00001309652,3.011187e-7,0.0003674696,9.638501e-7,0.9832295,0.00004396634,0.00004880757,0.0007965363],"study_design_scores_gemma":[0.0005395857,0.000071967,0.01275552,0.000115122,0.00002980478,0.00005266533,0.001127533,0.00001418724,0.9851698,0.00002602669,0.000008911316,0.00008886793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984279,0.001173624,0.0000575273,0.00003599629,0.00001257572,0.0001835942,0.00005473414,0.000004785716,0.00004932139],"genre_scores_gemma":[0.9994706,0.0002674886,0.00012109,0.00001200509,0.00001295755,0.000006253841,0.00009010424,0.000003930061,0.00001558858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002388062,"threshold_uncertainty_score":0.3495002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009472176152424228,"score_gpt":0.2117296007424276,"score_spread":0.2022574245900034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}