{"id":"W2080309793","doi":"10.1038/onc.2009.81","title":"The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Cancer Institute","keywords":"Biology; Ribosomal protein s6; Gene silencing; Retinoblastoma protein; Cancer research; Molecular biology; Kinase; Ribosomal s6 kinase; PI3K/AKT/mTOR pathway; Cell biology; P70-S6 Kinase 1; Signal transduction; Cell cycle; Cancer; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004432702,0.0001362678,0.0001101997,0.0000379037,0.0001158586,0.00002002463,0.000269474,0.00009886294,0.00004735103],"category_scores_gemma":[0.0000315447,0.0000897916,0.00008671499,0.0001161917,0.00006865847,0.00000357803,0.00001999859,0.0001614648,0.00001311012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006823899,"about_ca_system_score_gemma":0.0001296294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002408206,"about_ca_topic_score_gemma":0.00003476923,"domain_scores_codex":[0.9989005,0.00009365504,0.0002512532,0.0002656835,0.0002732303,0.0002156374],"domain_scores_gemma":[0.9994444,0.00001648023,0.0001237747,0.0003276692,0.00005313668,0.0000345836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001557481,0.00007299011,0.00003182914,0.00000491694,0.00001824683,0.000002283759,0.00005269086,0.00009111927,0.9941502,0.0002068072,0.0003377889,0.004875377],"study_design_scores_gemma":[0.0003688077,0.0004655248,0.0001513019,0.00004607104,0.000006946052,0.000005389262,0.00006255868,0.00000961914,0.9863486,0.0002171743,0.01220907,0.0001089728],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966981,0.0005161359,0.0001131849,0.001200107,0.0001866313,0.0004624323,0.00003709368,0.000005873355,0.0007804001],"genre_scores_gemma":[0.9982578,0.00005980051,0.0002062964,0.0003772319,0.0002451134,0.00007237906,0.00001267346,0.00001426591,0.0007544743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01187128,"threshold_uncertainty_score":0.3661595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539858790709999,"score_gpt":0.2509479100801202,"score_spread":0.2355493221730202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}