{"id":"W2080317557","doi":"10.1016/j.mce.2003.10.064","title":"IGF-I signaling prevents dehydroepiandrosterone (DHEA)-induced apoptosis in hypothalamic neurons","year":2003,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network; Canada Research Chairs","funders":"Canadian Institutes of Health Research","keywords":"Dehydroepiandrosterone; Protein kinase B; Endocrinology; Kinase; Internal medicine; GSK-3; PI3K/AKT/mTOR pathway; p38 mitogen-activated protein kinases; MAPK/ERK pathway; Apoptosis; Phosphorylation; Programmed cell death; Signal transduction; Protein kinase A; Chemistry; Cell biology; Biology; Androgen; Hormone; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001494906,0.000275955,0.0002704228,0.0001513749,0.00008727176,0.00002633653,0.0001374914,0.0001774993,0.00004538725],"category_scores_gemma":[0.0000714717,0.0002926003,0.0001336955,0.000147325,0.0000727369,0.000006740207,0.0000958705,0.0001856872,0.000009854984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002393646,"about_ca_system_score_gemma":0.0000648244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003016697,"about_ca_topic_score_gemma":0.00001080795,"domain_scores_codex":[0.998068,0.0003341826,0.0003222905,0.0005894936,0.0001270501,0.0005589531],"domain_scores_gemma":[0.9993892,0.00001185394,0.00008306235,0.0003618758,0.00003122093,0.0001227402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003384399,0.0000788486,0.001615444,0.00001829926,0.00004105899,0.00009078848,0.00002177867,0.0003072465,0.9960579,0.0006324862,0.00000787542,0.001094379],"study_design_scores_gemma":[0.001294161,0.0002543562,0.0002555655,0.00001781718,0.00002566726,0.0001301356,0.00002649761,0.00008270863,0.9958905,0.0004508819,0.001279104,0.0002925922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923409,0.00246541,0.00400255,0.00005752082,0.0001037505,0.0003278283,0.000004370666,0.00001933061,0.0006783191],"genre_scores_gemma":[0.9988405,0.00005177981,0.0005814402,0.0002102102,0.00002970806,0.0000564739,0.00005963548,0.00004142184,0.0001288536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006499557,"threshold_uncertainty_score":0.9999526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194264328858343,"score_gpt":0.2281555244408675,"score_spread":0.2162128811522841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}