{"id":"W2080324904","doi":"10.1016/j.molcel.2012.03.015","title":"Negative Feedback Loops: Nutrient Starvation Employs a New tr(IKK) to Inhibit PI3K","year":2012,"lang":"en","type":"letter","venue":"Molecular Cell","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Biology; Starvation; Nutrient; Cell biology; PI3K/AKT/mTOR pathway; Signal transduction; Ecology; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001316316,0.0008718757,0.0009023181,0.0002716458,0.0009068569,0.001499816,0.0009826379,0.00739943,0.002562494],"category_scores_gemma":[0.003561101,0.0002996783,0.0007516655,0.0001796365,0.001858735,0.001318196,0.0007020965,0.01073725,0.002193896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00157113,"about_ca_system_score_gemma":0.0005245631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003674476,"about_ca_topic_score_gemma":0.0006297247,"domain_scores_codex":[0.9994408,0.0001117782,0.00006244292,0.0001016673,0.000180465,0.0001027413],"domain_scores_gemma":[0.9988734,0.0006084682,0.0000957563,0.00009835878,0.0001489396,0.0001750212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003778595,0.0002982242,0.002974846,0.0004247267,0.0001626523,0.01656619,0.0002071205,0.0005604425,0.02702852,0.01748163,0.8048695,0.1256475],"study_design_scores_gemma":[0.003031336,0.001115872,0.003310566,0.0001982014,0.0002645902,0.02684866,0.0003874916,0.004132659,0.04318506,0.04894729,0.8683786,0.0001996624],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.01438757,0.01553257,0.003156816,0.9095262,0.04805954,0.0000555575,0.0001443855,0.0003937234,0.008743741],"genre_scores_gemma":[0.1809135,0.01340372,0.004217805,0.6727723,0.1035499,0.0002243761,0.000138489,0.0001045953,0.02467535],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00739943,"threshold_uncertainty_score":0.01139945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01103096935596904,"score_gpt":0.225382952280627,"score_spread":0.214351982924658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}