{"id":"W2080340090","doi":"10.1007/s00125-006-0374-5","title":"The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells","year":2006,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"Stem Cell Network; University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; University of Alberta; Stem Cell Network; Canadian Diabetes Association","keywords":"Sirolimus; PI3K/AKT/mTOR pathway; Pancreatic islets; Islet; Discovery and development of mTOR inhibitors; Function (biology); Cancer research; Internal medicine; Medicine; Cell biology; Chemistry; Endocrinology; Biology; Insulin; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002559476,0.0001904709,0.0002702482,0.0002125616,0.0001560959,0.0005524455,0.0001617032,0.0002527645,0.001234706],"category_scores_gemma":[0.0003825498,0.000144274,0.0002431264,0.000168864,0.000205251,0.0002961702,0.0001802637,0.0006461482,0.000348571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001907857,"about_ca_system_score_gemma":0.0002980909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003434918,"about_ca_topic_score_gemma":0.000560831,"domain_scores_codex":[0.9998186,0.00006016181,0.00001305795,0.000017851,0.00004850698,0.00004175788],"domain_scores_gemma":[0.9998046,0.00008083061,0.00002753466,0.00002194533,0.00001843456,0.00004669803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007230019,0.0002681623,0.003102195,0.0002355577,0.00006541648,0.0002739405,0.00007060391,0.0005770539,0.9254584,0.001053048,0.0008255472,0.06083996],"study_design_scores_gemma":[0.0003747343,0.005112387,0.1044823,0.00005615268,0.0002411363,0.001643315,0.0004004182,0.002444629,0.8594119,0.001024907,0.02477888,0.00002920044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760455,0.01677529,0.0002931599,0.0004812015,0.00008125997,0.000005897033,0.0002506949,0.00002893048,0.006038066],"genre_scores_gemma":[0.9882482,0.008132224,0.0003147512,0.0002237553,0.00007815702,0.000008418416,0.0004392194,0.00001747872,0.002538004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001234706,"threshold_uncertainty_score":0.004130542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008432411442389478,"score_gpt":0.2236482463600862,"score_spread":0.2152158349176967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}