{"id":"W2080362293","doi":"10.1016/j.molcel.2010.03.015","title":"The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I","year":2010,"lang":"en","type":"article","venue":"Molecular Cell","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children; Université Laval; SickKids Foundation; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Nucleoplasm; Nucleolus; Biology; Ribosome biogenesis; RNA polymerase I; Molecular biology; RNA polymerase II; Transcription (linguistics); Ribosomal RNA; Cell biology; 5.8S ribosomal RNA; Ribosome; RNA; RNA polymerase; Gene; Promoter; Gene expression; Genetics; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001665093,0.000189793,0.0001144638,0.00001745186,0.0003965618,0.0001162834,0.0004037355,0.0001147704,0.00004812869],"category_scores_gemma":[0.00004248318,0.0001211812,0.0001765599,0.00008528737,0.000155204,0.000005155996,0.00003809061,0.0001652881,0.00001281691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008462536,"about_ca_system_score_gemma":0.00004987379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006757303,"about_ca_topic_score_gemma":0.00003397674,"domain_scores_codex":[0.9988185,0.000106966,0.0002339785,0.0003398113,0.0001847787,0.0003159979],"domain_scores_gemma":[0.9989437,0.00002604503,0.0001199577,0.0007511049,0.00007350656,0.00008563289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003887818,0.00003795872,0.00005549143,0.00000464099,0.00003147332,0.000001447451,0.00002714106,0.00001362578,0.9953209,0.0001087145,0.00193137,0.002428401],"study_design_scores_gemma":[0.0004261149,0.00004793559,0.0002654593,0.000002069779,0.00002804877,0.000003976072,0.00004192479,0.0001274676,0.8725107,0.00004068981,0.1263508,0.000154777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908004,0.003890241,0.002116974,0.001397126,0.0003647646,0.0003523054,0.0001579772,0.00001670071,0.0009034724],"genre_scores_gemma":[0.9970798,0.00009738884,0.0001075693,0.0006046002,0.0001513909,0.0001182898,0.00008949469,0.00003750559,0.00171394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1244194,"threshold_uncertainty_score":0.4941626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005412591867295319,"score_gpt":0.2134102148302285,"score_spread":0.2079976229629332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}