{"id":"W2080417488","doi":"10.1111/j.1471-4159.2008.05851.x","title":"Helix 3 is necessary and sufficient for prion protein’s anti‐Bax function","year":2008,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institutes of Health; McGill University","keywords":"Helix (gastropod); Neurodegeneration; Function (biology); Bcl-2-associated X protein; Biology; Molecular biology; Chemistry; Biochemistry; Programmed cell death; Apoptosis; Cell biology; Medicine; Caspase 3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306726,0.0002291178,0.0002357617,0.0001374343,0.0002104885,0.000231809,0.0001309646,0.0002845125,0.001088301],"category_scores_gemma":[0.0002572994,0.0001271697,0.0002674703,0.00009099708,0.0002143449,0.000160602,0.0001698539,0.0003940227,0.0006820877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093962,"about_ca_system_score_gemma":0.0002644932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003949772,"about_ca_topic_score_gemma":0.0005148584,"domain_scores_codex":[0.9998592,0.00003125489,0.00001533746,0.00002156523,0.00003432786,0.00003819924],"domain_scores_gemma":[0.9995414,0.00009524055,0.0001722986,0.00004166346,0.00004104966,0.0001083263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002061838,0.00002377972,0.0007035324,0.00002575282,0.000005381568,0.0002562438,0.00001233346,0.00008022372,0.9979931,0.00006693438,0.00003286076,0.0005937337],"study_design_scores_gemma":[0.0001259789,0.0007056948,0.05744911,0.00003307498,0.00004182601,0.005537232,0.0001404925,0.002864843,0.9285581,0.0005365797,0.003980157,0.00002686429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981438,0.0003085552,0.0008589585,0.00004398708,0.00001191424,0.00000674003,0.000136816,0.00003478457,0.0004544603],"genre_scores_gemma":[0.9984144,0.00009125879,0.0007499867,0.0000238239,0.000007222708,0.000005848697,0.0004164588,0.0000100921,0.0002809267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088301,"threshold_uncertainty_score":0.003640711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286653997015253,"score_gpt":0.2383696507963545,"score_spread":0.225503110826202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}